Breaking News

Antiracist actions in STEMM, drug-pricing pilots, & the race against time to defeat Marburg illness

February 15, 2023
Reporter, Morning Rounds Writer

Good morning. Read on for the three big drug pricing reform experiments announced yesterday by the Biden administration.

science

'We must get beyond participation': National Academies report urges antiracist actions

To work against institutional racism in science and higher education, it's going to take much more than increasing the diversity of their populations, a sweeping new report from the National Academies of Sciences, Engineering, and Medicine warns. In addition to recruiting more people from underrepresented racial and ethnic groups to STEMM — science, technology, engineering, mathematics, and medicine — institutions must set in motion antiracist initiatives to breach barriers that have not only kept people of color from joining such institutions but once there, prevented them from succeeding and advancing in the ways their white colleagues have.

The report, released yesterday, comes when faculty members of color still report difficulty getting grants, white men still dominate top journals, and Black residents leave or are terminated from their programs at higher rates than white residents. "We must get beyond participation and aim for equitable and inclusive environments," said Gilda Barabino, report co-chair and president of Olin College of Engineering. STAT's Andrew Joseph has more.


policy

Biden administration will pilot three ways to lower drug prices

The Biden administration said yesterday it's rolling out three new policy experiments that would complement Democrats' drug pricing law passed last summer. The tests won't happen overnight, but will come alongside the effects of the law, which will take years to fully implement:

  • $2 drugs in Medicare: The agency plans to encourage Medicare prescription drug insurers to offer generic drugs for common chronic conditions such as hypertension for a flat $2 copay. 
  • Paying for cell and gene therapies: Like the treatments, this is more complicated. Cell and gene therapies are highly effective, but expensive. For the project, CMS would coordinate and administer multi-state agreements that would depend on outcomes — meaning states could potentially pay less if drugs don't work.
  • Accelerated approval: The agency plans to test a policy of paying less for drugs that receive so-called accelerated approvals than for drugs that are granted traditional approvals.

STAT's Rachel Cohrs and John Wilkerson have more.


infectious disease

Rare Marburg outbreak means racing to test vaccines and drugs

The "golden hour" in emergency medicine is 60 minutes after injury. For the Marburg fever outbreak in Equatorial Guinea, with no drugs or vaccines to combat it, every day counts. Some experimental vaccines and drugs have been shown in animals to prevent or treat Marburg, a deadly cousin of the deadly Ebola virus family. But finding out if they actually work in people requires an outbreak, and Marburg outbreaks are blessedly rare, STAT's Helen Branswell tells us. 

The current outbreak is believed to have begun in early January, but the confirmation that the Marburg virus was responsible came only on Monday. Nine people have died; another 16 people with some symptoms are in quarantine. (We were wrong yesterday on the possible cases). "I cannot emphasize enough the requirement for speed for doing any trials," John Edmunds of the London School of Hygiene and Tropical Medicine, said during a meeting yesterday organized by the WHO. Read more.



Closer Look

'Choices are getting more difficult' for physician practices, AMA chief says

amaWin McNamee/Getty Images

The AMA has descended on D.C. to make its case before Congress. STAT's Sarah Owermohle sat down with AMA President Jack Resneck to talk about legislative reforms, physician burnout, and where the doctors' lobby goes from here.

What are your thoughts on physicians selling their practices to insurers? 

Choices are actually getting more difficult and practices are finding themselves in positions where they feel like they have to sell to survive.

HHS Assistant Secretary Admiral Rachel Levine said at the conference that gender-affirming care is essential. What is your take?

This is what we do in medicine; we look at the evidence and help our patients. There's so much misinformation out there about what gender-affirming care is. So we are incredibly supportive. As with reproductive health care access, it is incredibly dangerous to have politicians putting in statute these things limiting what physicians can do.

Read the full interview here.


health

It's not just how long you sleep, but how consistent you are, study suggests

Getting a good night's sleep is a cornerstone of health, but "good" may have a new dimension. A study in today's Journal of the American Heart Association found an association between regular sleeping habits and atherosclerosis, in which fatty plaques narrow artery walls or form clots that block blood flow. Among more than 2,100 racially and ethnically diverse U.S. adults age 45 to 84, sleeping an irregular number of hours each night and falling asleep at varying times was linked to this precursor of heart attack and stroke.

People whose sleep duration varied by two hours or whose sleep start varied by 90 minutes within a week were more likely to have high coronary artery calcium scores. The study can't prove it, but the authors mention the power of circadian rhythms to affect health. They also say inconsistent sleep may be just one of many irregularly timed behaviors.


coronavirus

New-onset diabetes after Covid infection was lower for vaccinated patients

Developing diabetes after Covid-19 infection has been one of its more worrisome complications. A new study in JAMA Network Open confirms the association while suggesting Covid vaccination makes a difference. Looking at more than 23,000 patients infected through June 2022, the researchers found the risk of new-onset type 2 diabetes (when the body doesn't make enough insulin or grows resistant to it) was about 2.1% overall. But for unvaccinated patients, the risk was 2.7%, and for vaccinated patients, it was 1%. While the percentages are small, they translate into large numbers of people and if confirmed, add to the value of Covid vaccines.

Study co-author Susan Cheng asks whether Covid might be like a disease accelerator. "Instead of being diagnosed with diabetes by age 65, a person with preexisting risk factors for diabetes might — after a Covid-19 infection — be more likely to develop diabetes by age 45 or 55," she said in a statement.


by the numbers

feb. 14 cases covid-chart-export - 2023-02-14T172951.174


feb. 14 deathscovid-chart-export - 2023-02-14T173036.896

More around STAT
Check out more exclusive coverage with a STAT+ subscription
Read premium in-depth biotech, pharma, policy, and life science coverage and analysis with all of our STAT+ articles.

What we're reading

  • WHO abandons plans for crucial second phase of Covid-origins investigation, Nature

  • Quick-acting male birth control drug shows promise in the lab, Washington Post

  • 'This is the moment': Why an Amazon AI researcher is jumping to a medical scribe startup, STAT
  • Medicare advisers suggest tweaks to coverage process for Alzheimer's drugs, STAT

Thanks for reading! More tomorrow,


Enjoying Morning Rounds? Tell us about your experience
Continue reading the latest health & science news with the STAT app
Download on the App Store or get it on Google Play
STAT
STAT, 1 Exchange Place, Boston, MA
©2023, All Rights Reserved.

No comments