Breaking News

Hong Kong stymies ‘CRISPR babies’ scientist, demand for lab space wanes, & bats and viruses may be more enmeshed than we think

February 22, 2023
Reporter, Morning Rounds Writer
Good morning. If you find bats both fascinating as echolocating flyers and frightening as viral vectors, see what scientists have discovered about their "self-vaccination" abilities.

science

Hong Kong cancels visa of 'CRISPR babies' scientist trying to make a comeback

Chinese scientist He Jiankui ignited an ethical firestorm five years ago when he announced at a scientific meeting that he had genetically edited the embryos of twin girls. He was later sentenced by a Chinese court to three years in prison for practicing medicine without a license, but yesterday, 10 months after his release, he announced plans to study gene therapy for rare diseases in Hong Kong. He said he had secured a visa and was talking with universities, research institutes, and companies.

Not so fast: Hours later, Hong Kong revoked the visa. A government statement didn't name He, but said it was responding to reports about a visa applicant jailed for illegal medical practices who had made false statements, the Associated Press reports. As STAT's Megan Molteni told us late last year, He is intent on resuming his research despite widespread condemnation for breaching ethical barriers before the births of the first gene-edited children.


biotech

'We're out of whack': Demand for lab space slumping

A chart of real estate vacancies across top life sciences markets showing an uptick starting in 2022.

Cranes in the sky over biotech hotspots in many American cities have seemed like permanent fixtures, signifying demand for lab and office space that once seemed unquenchable. Now there's no denying the need is slowing. From San Diego to Boston, the industry's appetite for space has waned as public and private investment in biotech companies has slowed. After all, biotech stocks weathered double-digit declines in 2021 and 2022. "This is national. This is Boston. This is San Francisco. This is San Diego," said Greg Bisconti, an adviser to life science tenants for Jones Lang LaSalle, a commercial real estate services company. "We're out of whack." 

While the dip in demand is real, experts caution it is modest and likely to be short-lived, arguing that unused investment dollars, or "dry powder," are poised to ignite another period of rapid growth. Exactly when that might happen, however, is anyone's guess. STAT's Jonathan Wosen has more.


health tech

Tools to predict stroke don't work as well in Black patients

bloodstreams in a skull
Adobe

Heart disease and high blood pressure can be harbingers of stroke, so estimating patients' risk based on these factors can help guide preventive treatment. Doctors have long turned to formulas to gauge who might be vulnerable, increasingly based on machine learning. A recent study that compared newer algorithms to older ones found that with all models, the accuracy was worse for Black men and women than for their white peers. 

Black Americans already have a much higher probability of stroke, so if they are also less likely to get an accurate prediction of their stroke risk, they may miss out on appropriate stroke prevention and treatment. Study author Michael Pencina, director of Duke AI Health, said the issue isn't technology to predict strokes but rather datasets on which they are based that don't include relevant risk factors such as chronic stress and social determinants of health. STAT's Ambar Castillo has more



Closer Look

Opinion: Use 'racial privilege' — not race — to measure and understand health

When Elizabeth A. Brown goes to a health care provider and checks "Black" for her race or ethnicity, she says it tells her provider — before seeing her — she has dark skin and "different" hair. But ticking that box could also queue up stereotypes, including assumptions that she has no husband, little education, or low or no income. What would be far more helpful than a race checkbox is a racial privilege index, Brown, an assistant professor at Old Dominion University, writes in a STAT First Opinion.

"A racial privilege score would be the sum of an individual's lived social experiences, treatment based on race, socioeconomic status, and other factors, similar to how various factors or behaviors produce a credit score," she says. "Racial disparities are not a consequence of Black skin but a consequence of treatment because of Black skin, I continuously tell myself and the students I teach." Read more.


public health

Study: Celebrity tweets shaped opinions on Covid

Just as the FDA is taking on misinformation, a new study in BMJ Health & Care Informatics reminds us that people in the public eye have the power to sway opinions on health despite being famous for other reasons. Researchers analyzed tweets that mentioned anti-vaccine stances taken by public figures in entertainment, sports, politics, and news. They found consistent patterns of emotional content shared by celebrities that they conclude influenced public opinion.

As they call for better public health messaging, the authors note tweets from people responding to celebrities can go both ways: 
  • "I love how the same people who don't want us to listen to Joe Rogan, Aaron Rodgers about the covid vaccine, want us to listen to Big Bird & Elmo."
  • "I called Ted Cruz's office asking to make an appointment to talk with the Senator about my blood pressure. They told me that the Senator was not qualified to give medical advice and that I should call my doctor. So I asked them to stop advising about vaccines."

in the lab

Bats and viruses may be more intertwined than we thought, study hints

If you've been baffled by how bats can harbor and spread viruses like SARS-CoV-2 with no ill effects to themselves, you're not alone. And whatever views one holds on the origins of Covid-19, the specter of more diseases spilling over to humans from bats and other creatures is enough to animate interest in this Cell paper. It describes what scientists learned when they created the first induced pluripotent stem cells from two types of bats (the wild greater horseshoe bat and the greater mouse-eared bat).

Bats deploy "self-vaccination," their experiments in lab dishes suggest, which means their stem cells may produce viral proteins to train their immune systems to tolerate and survive viruses — both SARS 1 and 2, MERS, Marburg, and more — that can sicken and kill other mammals. Bats may have a more intertwined, symbiotic relationship with viruses than anyone suspected, these discoveries hint, with more work to come on how this might bear on future pandemics.


We had an incorrect link yesterday to STAT contributor Jill Neimark's story on the potential health hazards posed by chemicals in the Ohio train derailment. Read the story here.


by the numbers 

feb. 21 cases covid-chart-export - 2023-02-21T173934.559

 

feb. 21 deaths covid-chart-export - 2023-02-21T174001.606


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What we're reading

  • Why are nurses quitting? Ask the nurse no hospital will hire, Washington Post
  • Ian Fishback's American nightmare, New York Times
  • Dutch group sues AbbVie for human rights violations traced to Humira pricing, STAT
  • U.S. plans to allow Medicaid for drug treatment in prisons, Associated Press
  • Opinion: Needed for national security and competitiveness: a federal biodata infrastructure, STAT

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