Breaking News

Pursuing precision obesity medicine, the history of BMI, & looking at limits on lab research

March 9, 2023
Reporter, Morning Rounds Writer
Good morning. The Obesity Revolution is just getting started and so are we. Read what might follow failed one-size-fits-all treatments and watch how BMI came to be.

the obesity revolution

Pursuing the dream of precision obesity medicine

Illustration of abstract person stating center surrounded by different colors and shapes.
Katy Lemay for STAT

Anne's story is uniquely her own, but she's not alone. Her doctor, Andres Acosta, listened to her complicated medical history to understand why, at 68, she weighed much more than she did in her 20s, causing her knees to ache and her blood pressure and cholesterol to soar. He suspects her sluggish metabolic rate combined with her apparent emotional eating — not a lack of willpower — are the root cause. She'll need more than the standard "eat less, move more" prescription many patients with obesity get. 

"We know that 'one size fits all' is not working," Acosta told STAT contributor Julia Belluz for the second story in our series The Obesity Revolution. Read how clinicians are trying to break obesity into subtypes to better tailor treatments to people like Anne — and what critics say about this approach. And don't miss the video (highlighted below) explaining BMI.


politics

House coronavirus panel urged to limit research

The world is still divided over what sparked the Covid-19 pandemic, but one former government official told a revamped House committee on the coronavirus he's certain that gain-of-function research, in which pathogens are altered in a lab, is to blame rather than the coronavirus spreading from animals to people. "I think it's caused the greatest pandemic we've ever seen," said Robert Redfield, a virologist who was CDC director during the Trump administration.

Redfield urged a "moratorium" on gain-of-function research, arguing it has no value in preparing for infectious disease outbreaks. Democrats did not discount the possibility of an accidental lab leak, but instead steered the hearing toward increased laboratory oversight and early Trump administration missteps rather than research limits. Republicans pointed to former top infectious disease official Anthony Fauci, arguing that his agency funded risky gain-of-function research — which he has denied. STAT's Sarah Owermohle has more on the fray.


health

How an androgen treatment for trans men may help protect against breast cancer

It seems logical that when transgender men transition, their risk of breast cancer plunges after chest reconstruction surgery. But new research in Cell Genomics points to androgens taken during hormone replacement therapy, raising hope they might also help treat or prevent breast cancer. STAT's Angus Chen recently spoke with study co-author Simon Knott of Cedars-Sinai Medical Center.

What does your work mean for breast cancer?

That tells us androgen therapy and activation of androgen receptors counteract estrogen receptor signaling. ER signaling and an overabundance of it is probably one of the greatest causes of breast cancer.

What's next?

Studying breakthrough cases — where trans men have actually gotten a breast cancer. It would be worth looking at the breast tissue of trans women who typically receive high doses of feminizing hormones like estrogen. Understanding the molecular mechanisms underlying that — and the reciprocal action of androgen — might better elucidate how these two hormones interact.

Read the full interview.



closer look

The troubled history of the body mass index

Hyacinth Empinada/STAT

Most people might struggle to recall the math behind the BMI, but just about everybody knows it's a measure that tops out with the highest rates of obesity. It's been getting pushback for years, with some experts saying waist-hip circumference is a better indicator of the link between weight and health. Perhaps the best example would be athletes, whose muscular body composition pushes them into obese territory faster than others.

"I think we have been too fixated on BMI. ​​For the most part, BMI seems to be very good at the population level, but at the individual level, it's not that good," Francisco Lopez-Jiminez of the Mayo Clinic told STAT's Hyacinth Empinado. Her video explores and explains the history of this ubiquitous metric — originally called the Quetelet Index and initially used most by insurance companies — and its development based on European populations, limiting its usefulness for other groups. Watch here.


policy

The FDA says it's all in for battling misinformation. What can it do?

Medical misinformation isn't new, but it has certainly metastasized in today's supercharged online world. "Anybody with an opinion now can reach, you know, a billion people in 10 minutes," FDA Commissioner Robert Califf told STAT contributor Ben Brody. "That's just a whole different world." Califf said the agency is working — within limits — to decide how best to deal with misinformation such as vaccine skepticism and its deadly impact on the Covid-19 pandemic. 

Those limits are both legal and political, Califf and other experts said. Taking aim at platforms like Twitter, Instagram, and TikTok may be on legally shaky ground — and could provoke a political backlash. "Putting pressure on companies is not something that we can do unless there's a specific law that directs us to do it," said Califf, who led medical strategy at Google's parent company after his first stint running the agency ended in 2017. Read more on the issues and who they might be addressed.


health

Racial gaps widen among children injured by guns 

Gun violence is still the leading cause of death among children. Let that sink in (again) before taking in new research that tells us racial disparities in the risk of firearm injury have widened so much that in December 2021 Black children were nearly 100 times more likely to be shot than white children. That gap's up from 27 times more likely before Covid hit. For the same time period, the risk of firearm injury tripled between Hispanic children and white children, and nearly tripled between Asian children and white children.

The research letter in JAMA Network Open, which looked at gun violence in New York City, Chicago, Los Angeles, and Philadelphia, echoes previous research, but there's one difference: There was no increase in gun injuries among white children during the first 21 months of the pandemic. The authors say social advantage and neighborhood context may shield white children from gun violence.


by the numbers

We are pausing our Covid charts for technical reasons today.


More around STAT
Check out more exclusive coverage with a STAT+ subscription
Read premium in-depth biotech, pharma, policy, and life science coverage and analysis with all of our STAT+ articles.

What we're reading

  • Walgreens drew a line on abortion pill access and is paying a price, Washington Post
  • Pfizer CEO Albert Bourla maxed out campaign contributions to Dr. Oz ahead of midterm elections, STAT
  • HHS secretary signals support for new restriction on addiction treatment, STAT
  • Where there's gender equality, people tend to live longer, NPR

  • Medicare chief on the new drug price negotiation program's operations, hiring, and timelines, STAT

Thanks for reading! More tomorrow,


Enjoying Morning Rounds? Tell us about your experience
Continue reading the latest health & science news with the STAT app
Download on the App Store or get it on Google Play
STAT
STAT, 1 Exchange Place, Boston, MA
©2023, All Rights Reserved.

No comments