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How Lilly's Alzheimer's drug worked, what Biden's NIH pick will face, & ideas against poaching health care workers from the Global South

May 3, 2023
Reporter, Morning Rounds Writer
Good morning. The "First Opinion Podcast" is back today. In her first episode as host, editor Torie Bosch speaks to two medical residents who debate their hospital's unionization drive.

drug development

Lilly's Alzheimer's drug shows strong trial results but also safety concerns

A new treatment for Alzheimer's disease developed by Eli Lilly posted impressive results yesterday, slowing patients' rate of cognitive and functional decline by 35% compared to placebo, but those gains came with safety concerns. Two patients, and possibly a third, died as a result of a type of brain swelling caused by these drugs.

Today's results appeared via company press release so they haven't been vetted by scientists outside Lilly. The company said the data will be used to file for full FDA approval before the end of June. The drug, known as donanemab, will compete with another Alzheimer's treatment from Eisai and Biogen, Leqembi, which won FDA approval in January. Both follow the first amyloid-blocking drug, Aduhelm, whose rollout has been a failure. STAT's Adam Feuerstein and Matthew Herper have more.


politics

Biden's pick to lead NIH will face political grilling

AP22280684932676Jeff Chiu/AP

President Biden's presumed pick to lead the NIH will undoubtedly face a political gauntlet of questions about the giant agency she'll lead if confirmed, but her first round won't be this week. Monica Bertagnolli (above), who now heads the National Cancer Institute, has been vetted for the role and her nomination was planned for last month, sources told STAT's Sarah Owermohle, but she won't make tomorrow's Senate hearing because of previously scheduled routine cancer treatment. 

The NIH role has been vacant since Francis Collins stepped down in December 2021, leaving behind a well-funded agency whose culture has been criticized as too bureaucratic and whose Covid research has been controversial, even apart from the lightning rod that is Covid's origin. "Turning around a battleship — and that's what the NIH is — is a daunting task for anybody," said Liz Feld, former president of cancer advocacy group Suzanne Wright Foundation. Read more.


mental Health

Suicide-related ED visits are way up among youths

The numbers look uniformly horrific: ED visits related to suicide soared fivefold from 2011 to 2020 among children and adults from 6 to 24 years old. They rose across all age groups, sex, race and ethnicity, insurance type, and geography, yesterday's JAMA study said. Looking more broadly, the proportion of ED visits for mental health reasons nearly doubled from 2011 to 2022 among children, adolescents, and young adults to 13.1% of all ED visits for this age group. The proportion of all types of mental health-related ED visits, including those related to mood, non-suicidal behavior, substance use, and psychosis, also increased significantly.

But here's a grain of hopeful salt: Maybe people are more likely to seek help now, and more of them might have insurance to cover it, Greg Simon of Kaiser Permanente told STAT's Ambar Castillo, even though the ED is not the ideal place to get care. Read more.


If you or someone you know may be considering suicide, contact the 988 Suicide & Crisis Lifeline: call or text 988 or chat 988lifeline.org. For TTY users: Use your preferred relay service or dial 711 then 988.



Closer Look

Opinion: Stealing health care workers from the Global South is no solution

You're no doubt aware the U.S. is experiencing an acute shortage of health care workers. That's also true in the U.K., faced with strikes by nurses and junior doctors, and in much of Europe. What these countries have in common is how they are filling their gaps: Many are recruiting from the Global South. Already 15% of health care workers work outside their country of birth. 

That can hurt those left behind, Vanessa Kerry, the CEO of Seed Global Health and a physician at Massachusetts General Hospital, and Travis Bias, a family medicine physician who has taught medicine in Uganda and Kenya, write in a STAT First Opinion. "The labor pull to higher-income countries leaves lower-income countries less able to meet the burden of disease and undermines economic and social stability," they say. "High-income countries need to commit to training and hiring more of their own workers." Read more.


health

Room for improvement in reducing cancer risk, analysis says

The American Cancer Society brings us both good news and bad in its new  report on risk factors, preventive behaviors, and access to care for cancer. Starting on the cusp of the Covid-19 pandemic, the analysis found that smoking, alcohol use, and physical inactivity went down from 2019 to 2021, but the prevalence of obesity went up and cervical cancer screening went down during the same period. There were disparities:

  • People without health insurance were 28% to 60% less likely to be current with recommended cancer screening compared to people with private health insurance.
  • People with less than a high school education, who are four to five times more likely to smoke than people with a college education, did not see changes in smoking. 
For context, the report says, 45% of the more than 600,000 U.S. cancer deaths expected this year can be attributed to avoidable risk factors.

science

Social safety nets can narrow gaps in kids' brain development, study says

It makes intuitive sense that family income is tied to children's mental health when you think about stress and opportunities influenced by what money can buy. Research has linked brain anatomy, too, to income, associating lower volume in the hippocampus — critical in memory and emotional learning — to lower income. A new study in Nature Communications goes a step further, identifying a connection between anti-poverty programs and disparities in brain development and mental health symptoms.

The researchers, who studied 10,000 children age 9 to 11 in 17 states with varying costs of living and anti-poverty policies, expected the biggest disparities to show up in states with the highest cost of living. Instead, more expensive states that had anti-poverty programs had narrower gaps in income-associated differences in brain structure. And mental health symptoms like anxiety and depression were 48% lower in expensive states whose social safety nets had larger cash benefits than in states with lower cash benefits.


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What we're reading

  • Vermont allows out-of-staters to use assisted suicide law, Associated Press

  • Why viral reservoirs are a prime suspect for long Covid sleuths, NPR

  • Legal battle between Apple and Masimo over trade secrets ends in mistrial, STAT
  • 93 days: The summer America lost Roe v. Wade, The 19th
  • Disagreements and digs upend an otherwise bipartisan hearing on PBM reform, STAT

Thanks for reading! More tomorrow,


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