Breaking News

A push for a translational science center, the restorative power of hospital gardens, & why buprenorphine prescriptions aren't rising

July 24, 2023
Reporter, Morning Rounds Writer
Good morning. Hospital gardens have plenty of data backing their value, but I'm not sure many of us need convincing when it comes to their restorative powers. Be sure to read Isabella Cueto's story from LA and watch Hyacinth Empinado and Alissa Ambrose's video from Boston.

politics

To move discoveries into medicine, don't forget NIH center for translational research, lobbying group says

One of the knocks on NIH has been its less than nimble approach to innovation. The nation's biggest science agency is not known for taking big risks that could deliver medicine-changing discoveries — or seismic failures. But there's the new, well-funded Advanced Research Projects Agency for Health, right? Yes, but Christopher Austin wants to remind Congress of the National Center for Advancing Translational Sciences. Founded in 2011, its mission is also to turn lab discoveries into medical practices. 

Austin was the center's first director, but after leaving in 2021, he's now at Flagship Pioneering and leads the NCATS Alliance, whose goal is to win a 16% funding bump in 2024 for the translational center and remind Congress of its complementary role to ARPA-H. "Part of how ARPA-H worked out, in my opinion, came from learnings on what worked and what didn't at NCATS," said Austin. STAT's Sarah Owermohle has more.


drug shortages

Tornado update: A Pfizer warehouse took the biggest hit in North Carolina storm

It could have been worse. The tornado that tore through a key Pfizer plant in North Carolina did not cause "any major damage" to areas that produce medicines, the company said, because most damage occurred at a warehouse. It's still unclear how destruction at the facility — which makes nearly 8% of all sterile injectables used in U.S. hospitals — will affect the prescription drug shortage.

The FDA said its initial analysis has identified fewer than 10 drugs for which Pfizer's North Carolina plant is the sole source for the U.S. market, but there should be substitutes or many weeks' worth of stock in Pfizer's other warehouses for some specific formulations. "We do not expect there to be any immediate significant impacts on supply given the products are currently at hospitals and in the distribution system, but this is a dynamic situation," Commissioner Robert Califf said in a statement Friday night. STAT's Ed Silverman has more.


addiction

Hurdle removed, providers are still reluctant to prescribe buprenorphine for addiction

The number of prescribers may have bumped up, but the actual number of people getting prescriptions for the addiction medication buprenorphine hasn't budged significantly, a new study in JAMA Health Forum says. It's now much easier to provide buprenorphine, the only medication available outside a specialized clinic that treats opioid addiction by helping to reduce cravings and withdrawal symptoms. To name one: Prescribers no longer need special training to obtain a special license just to prescribe it. 

Other obstacles remain, the study authors found, including concerns about DEA overreach, insurance approval processes, lack of institutional support,  buprenorphine misuse, and treating patients with opioid use disorder. "We also need to do education and engagement around how to manage patients with opioid use disorder so that providers feel more comfortable," study co-author Chris Jones said. "Not only among clinicians, but among patients." STAT's Lev Facher has more.



Closer Look

Hospital gardens: 'A place of rest for the weary-hearted and weak-limbed'

0453_BCH-gardens-STILLHyacinth Empinado/STAT

A hospital garden can be many things, STAT's Isabella Cueto writes. At UCLA, it's a semi-wild botanical garden. At Cedars-Sinai in Los Angeles, it's a prescriptive, meticulous arrangement of aesthetically pleasing plants and seating. The one on the roof of Boston Medical Center is a communal effort, with produce and herbs sprouting from soil turned by many hands. At Boston Children's Hospital, a new garden (above) can be seen as an attempt at reconciliation after an old and beloved space was redeveloped. 

"Overall, a hospital garden should provide an environment as different as possible from the straight lines, muted colors, and sanitized — perhaps fearful — atmosphere of a hospital interior," former UC Berkeley professor Clare Marcus Cooper said. "A garden can be a place of rest for the weary-hearted and weak-limbed, for the hopeless and finger-crossed," STAT's Isabella Cueto writes. Read more, and watch a video from Hyacinth Empinado and Alissa Ambrose focused on Boston Children's. 


health

Opinion: How doctors' personal politics affect patients' care

DEMREP_DRAlex Hogan/STAT

President Ronald Reagan delivered a quip while being wheeled into an operating room after being shot in 1981. "Please tell me you're all Republicans," he said to the OR team. They laughed. "Today, we're all Republicans, Mr. President," a (Democratic) surgeon replied, reassuring his patient that political disagreements would not matter. Anupam Jena and Christopher Worsham of  Harvard Medical School relate that anecdote in a STAT First Opinion essay adapted from their book, "Random Acts of Medicine: The Hidden Forces That Sway Doctors, Impact Patients, and Shape Our Health." 

Caring for a president is unlikely to be controversial, but what about more politically divisive topics? A survey that found Republican doctors perceived patients who had had prior abortions to have more "serious" medical issues than Democratic doctors while Democratic doctors perceived the presence of firearms in the home to be more concerning than Republican doctors. Read more on how politics do and don't come into play.


infectious disease

HIV studies test statins and look at the risk of transmission from low viral loads

Two studies timed to the 2023 International AIDS Society Meeting in Australia this weekend:

  • In NEJM, researchers report that a phase 3 trial testing pitavastatin, a drug that lowers "bad" cholesterol, found that people with HIV on antiretroviral therapy who took pitavastatin had a lower risk of a major adverse cardiovascular event than those who got a placebo. That's important because people with HIV carry up to twice the risk of cardiovascular disease as those without HIV.  
  • In The Lancet, researchers conclude that people on antiretroviral therapy who have low but detectable levels of HIV have almost zero risk of transmitting the infection to others. The study also confirms previous work that found zero risk of transmitting the virus to sexual partners when the viral load is undetectable. "These data provide a powerful opportunity to destigmatise HIV and promote adherence to ART," the authors write, cautioning that their results do not apply to mother-to-child transmission.
    Correction: In Friday's newsletter we got the name of the North Carolina town where a tornado hit a Pfizer plant wrong. It's Rocky Mount.

More around STAT
Check out more exclusive coverage with a STAT+ subscription
Read premium in-depth biotech, pharma, policy, and life science coverage and analysis with all of our STAT+ articles.

What we're reading

  • Children were safer around guns after watching a 1-minute video, Washington Post
  • White House launches permanent pandemic office, STAT
  • Hospices in four states to receive extra scrutiny over concerns of fraud, waste and abuse, ProPublica

  • FDA official pushes for a dedicated emerging pathogens team to prepare for the next pandemic, STAT

Thanks for reading! More tomorrow,


Enjoying Morning Rounds? Tell us about your experience
Continue reading the latest health & science news with the STAT app
Download on the App Store or get it on Google Play
STAT
STAT, 1 Exchange Place, Boston, MA
©2023, All Rights Reserved.

No comments