Breaking News

The message from the McConnell episode, meat allergies up after tick bites, & OB-GYNs aren't referring patients to out-of-state abortions

July 28, 2023
Reporter, Morning Rounds Writer
Good morning. On tap today are experts' thoughts on McConnell's moment, a report saying what all of government needs to do to ease health inequities, and what's looking like a digital health success story.

Health

Response to McConnell episode worries experts

Mitch McConnellJ. Scott Applewhite/AP

We're not sure what happened Wednesday when Senate Minority Leader Mitch McConnell (above) froze, stopped speaking, and left the press conference he'd just started leading. He returned in moments, his aides said he'd just felt light-headed, but the incident has sparked not just concern about the 81-year-old's health (given his history of concussion), but also alarm about ignoring what could be symptoms requiring prompt medical attention. McConnell's office did not respond to STAT's request for comment on whether he was examined by a doctor before coming back behind the podium.

"When you see something like that, which is essentially a neurological event — we don't know what it was, but his brain malfunctioned — you always assume the worst, not because that's the most likely cause, but you want to address the things that are the most immediate threat," said Bernard Ashby of the University of Miami. STAT's Annalisa Merelli has more.


health 

Advancing health equity requires all of government, not just health agencies, report advises

It's long past time to document how poverty and racism affect health, the federal agency overseeing minority health told the National Academies of Science, Engineering, and Medicine when commissioning an analysis. Instead, what's needed now is a detailed roadmap to closing deep health disparities. In its report out yesterday, the group says improving health equity cannot be accomplished by the government's health agencies alone. 

"It is a much deeper problem," said Sheila Burke, who led the committee writing the report. "One of the things that was important to us was not to say, 'This all gets solved by health insurance.' Credit scores, incarceration policies — these all contribute to health inequities." Recommendations include urging:

  • Congress to create a scorecard for how new laws might affect health equity.
  • CDC to help increase measurements of social determinants of health.
  • And the Office of Management and Budget to oversee efforts to improve data collection. 

STAT's Usha Lee McFarling has more.


in the lab

Coming closer to a single-injection gene-editing treatment for diseases like sickle cell

Here's the dream: Curing a disease like sickle cell with one shot. Scientists call it in vivo cellular reprogramming, and it's a way to change how cells function (or malfunction) with a single injection rather than manipulating them outside the body. Sickle cell disease right now is the subject of excitement over ex vivo gene therapy, a treatment that means suppressing a patient's immune system, pulling out some cells, editing them in a lab, and reinfusing them at a cost of millions.

A new Science study in mice describes another way: using lipid nanoparticles to carry mRNA into hematopoietic stem cells in the bone marrow, where they correct sickle-cell defects. The mRNA cargo quickly produced a fast-acting base editor for precisely fixing cells' DNA — permanently. "Almost like a hit-and-run gene therapy," said Paula Cannon, a gene therapy researcher at the University of Southern California's Keck School of Medicine who was not involved with the research. STAT's Isabella Cueto explains.



Closer Look

Talkspace builds its case for becoming a digital health success story

Talkspace might not be turning a profit yet, but the once-embattled virtual mental health company is looking like a winner among startups born in the 2021 digital health boom. After investors infused a record $29 billion into the sector, some have not emerged in an uncertain economy, including Pear Therapeutics, which went bankrupt earlier this year, and Headspace, a Talkspace competitor, which recently laid off employees and took on $105 million in debt.

In contrast, Talkspace, whose main business is providing therapy over text chat and audio and video connections, projects breaking even on an adjusted basis with more than $100 million in cash in the bank. "We obviously will emerge as one of the survivors," Talkspace CEO Jon Cohen told STAT's Mario Aguilar. Read more, including how a mental health entrepreneur compares the current moment in digital health to 2001, when markets collapsed around a crop of early internet companies.


public health

Alpha-gal syndrome, that allergy to meat and dairy after a tick bite, is rising

Of all the bizarre ways we humans interact with other creatures on this warming Earth, the sensitivity to a substance found in meat and dairy (and tick saliva) after being bitten by a tick has to rank high on the list. A new CDC report tells us a​​lpha-gal syndrome, short for allergy to the sugar galactose-alpha-1,3-galactose, has climbed 41% from 2017 to 2021. A survey also released yesterday found that 42% of health care providers didn't know about the syndrome and another 35% weren't too confident about how to diagnose and treat it.

This sensitivity shows up long after inflammation from the tick bite subsides because the antibody to alpha gal sticks around. There are no cures or treatments for the condition, and allergies often last for years, potentially causing hives, nausea and vomiting, upset stomach and diarrhea, and in extreme cases, anaphylaxis. STAT's Bree Iskandar has more.


reproductive health

Opinion: Too many doctors in states that ban abortion refuse to make legal referrals

For a year now, the news about abortion has been dominated by restrictions on the procedure, limitations on medication abortion, and the consequences for people in states where options are collapsing. Here's the thing, three authors of a STAT First Opinion say: Abortion is still accessible even in states that ban it because there are options like traveling to the two-thirds of states where it's legal or ordering medications internationally to end early pregnancies at home.

Patients — especially the most vulnerable — may not know this and doctors may not tell them. "Doctors' silence violates their central ethical obligations to respect patients' autonomy, advance justice, and promote beneficence," Michelle Oberman of Santa Clara University, Katie Watson of Northwestern Medical School, and Lisa Lehmann of Harvard Medical School write. "It is unjust for doctors to leave those with lower health literacy unable to exercise the options available to more educated patients." Read more. 


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What we're reading

  • Fatigue can shatter a person, The Atlantic
  • Their families said they needed treatment. Mississippi officials threw them in jail without charges, ProPublica
  • Adam's Take: A conflict of interest behind the warning on Apellis' eye drug? The optics are not good, STAT
  • After Bronny James' cardiac arrest, here's what doctors know about heart issues in elite athletes, The Athletic
  • Lawmakers circle parents' rights in gender-affirming care hearing, STAT
  • Biden announces an advanced cancer research initiative as part of the bipartisan 'moonshot' effort, Associated Press

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