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PhRMA bristles at FDA’s importation estimates, side effect subtitles, and calls for kidney care in stockpile

August 8, 2023
Reporter, D.C. Diagnosis Writer

Hello and happy Tuesday, D.C. Diagnosis readers! Everything comes back to health care … even hit kitchen-drama T.V. show The Bear. Send news and tips to sarah.owermohle@statnews.com — thanks, chef.

drug costs

FDA analyzing importation

Like the August recess, the fall budget battles and all our other seasons, some things just always come back around. Yes, we're talking about drug importation again.

Monday marked the FDA's deadline for comment on its tracking of the impact that importing drugs from Canada could have on medications' prices and safety. While it's a relatively incremental change to FDA's information collection on this topic, it highlights the ongoing debate around importation — and the fact that the agency hasn't approved any state's plan to import from Canada, despite starting this process in 2020.

It also provides another outlet for the drug industry to vent its frustration about the possibility of state importation. PhRMA wrote in comments shared with STAT that the FDA's latest projection is "inconsistent" with earlier estimates and still underestimates the burden this puts on manufacturers or importers. The lobby urged the White House's budget office to nix the info collecting extension.

Elsewhere, during a rare in-person meeting of the White House's drug shortage task force Friday, temporary drug importation also came up. My colleague John Wilkerson has the scoop on that meeting, here.


straight to consumer 

Will drug ads go the way of foreign flicks?

The Food and Drug Administration might soon decide whether to require subtitles about side effects during television drug commercials, which hopefully would be more helpful than that time the BBC subtitled comments by French President Emmanuel Macron as "speaks French."

Details of the final rule are not public, and my colleague John Wilkerson reports that it's difficult to predict what the FDA plans to do, given that the agency stopped accepting public comments on the rule in 2012.

Over the years, the FDA has said that research suggests viewers understand side effects better when subtitles are added to commercials. That same research did not show that images of happy, active patients distract attention from side effects, according to the FDA. Agency officials also have said they are considering shortening side effect information in ads because the risk of truly serious side effects might sink in better if less-serious side effects are left out. Read more.


emergency prep

Kidney doctors: Covid proves stockpile needs, again

When New York City hospitals ran out of dialysis machines in the early, shutdown days of the pandemic, the federal government had some. A fortuitous 2019 contract meant the strategic national stockpile had 50 user-friendly dialysis machines to ship to New York and surrounding areas as the virus wreaked havoc on kidneys and well as lungs and and other organs. Now, advocates are questioning why the stockpile isn't reinvesting. 

Dialysis machines were part of the stockpile from 2019 to 2022 but were not renewed for this year, with no explanation, Carrie Arnold writes for STAT News. That's even after infrastructure-destroying hurricanes like Katrina made the need for emergency equipment clear, doctors say. 

But as Congress hashes out the Pandemic and All-Hazards Preparedness Reauthorization Act — which funds the stockpile — some fear that the 550,000 people on dialysis in the U.S. will again be overlooked. More from Carrie.



mental health crisis

FDA fences in rapid-acting depression drug

The agency on Friday approved a 12-day pill regimen, Zurzuvae, to treat postpartum depression but rejected Sage Therapeutics' bid for approval in the broader pool of major depressive order patients. And the company isn't happy

"We don't agree with the FDA review," Sage CEO Barry Greene said Monday during an earnings call, a point he made repeatedly, according to STAT's Brittany Trang. "We are evaluating the [FDA's response letter] and as soon as we can provide more clarity, we will, on what the next steps are."

Zurzuvae showed pretty clear benefits in the postpartum population but hazy results in the larger group, though the company argued a chunk of trial participants weren't taking it regularly. It's the latest therapy to treat depression or anxiety to go for FDA review, with others hot on its heels — another company on Monday posted positive late-stage results for a nasal spray to treat social anxiety. But the next hurdle: Pricing the drug, the first-take-home medication for postpartum depression.


More around STAT
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What we're reading

  • Medicare slashes safety net hospital payments on estimate that more people have insurance, STAT
  • Pandemic slowed cancer diagnoses, but late-stage cancers came back with a vengeance, STAT
  • The NIH halts a research project. Is it self-censorship? KKF Health News
  • Community health workers, experts in the in-between, fight for their place in the system, STAT
  • Texas ruling would allow abortion during dangerous pregnancy complications, The 19th News

Thanks for reading! More on Thursday,


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