Breaking News

The big day for Medicare drug price negotiation

August 29, 2023
Reporter, Morning Rounds Writer
Good morning. We're watching for the the first drugs on Medicare's negotiation list and also looking at cancer screening and what could be a novel adaptation of advance directives. 

drug prices

White House to name 10 drugs whose prices Medicare can negotiate

Today's the day: This morning the Biden administration is expected to announce its list of the first 10 prescription drugs whose prices Medicare can negotiate, one year after the president called passage of the Inflation Reduction Act a BFD. The law would make the U.S. more like many other high-income countries that can leverage discounts from drugmakers.

So far, six drug companies have gone to court to challenge the law, which says medicines are eligible for selection if they are one of the highest-spend drugs for Medicare and have no generic competition. The drugmakers are fighting the law on constitutional grounds while arguing in the court of public opinion that their pipelines of new and innovative drugs will run dry. STAT's politics and biotech teams will have more later today, so stay tuned to statnews.com.


cancer

Screening tests may not extend lives, except for one 

Cancer screening tests are considered a pillar of health care, praised for saving lives by catching malignancies early. A new systematic review in JAMA Internal Medicine of 18 long-term studies involving 2.1 million people looked to see whether tests for breast, colorectal, lung, prostate, and cervical cancer led to longer lives. The answer is no, with the exception of sigmoidoscopy to detect colorectal cancer, which prolonged life by about three months. The authors say the follow-up of 10 to 15 years may not have been long enough, but they also note that screening tests have harms, too, including overdiagnosis.

On that same theme, two studies in the Annals of Internal Medicine found that adding AI to colonoscopies to find polyps and cancer improved detection of polyps and increased their removal, but it did not add up to more detection of advanced adenomas, the types of polyps with higher risk of cancer progression.


reproductive Health

Biomarker found for preeclampsia early in pregnancy 

Preeclampsia is a dangerous complication of pregnancy that sends blood pressure soaring and leads to maternal and infant deaths. Taking low-dose aspirin early in pregnancy can help, but detecting who's vulnerable is challenging before symptoms arise. There is a blood test once blood pressure surges later in pregnancy, but nothing for the 12% who develop it in the first trimester and have a higher risk of problems later. 

A new case-control study in Nature Medicine testing a liquid-biopsy approach to measure differences in DNA-methylation levels in the blood found it could predict 72% of patients with early-onset preeclampsia. The work is based on previous research that identified changes to DNA methylation in the placenta at delivery, which differed between those with and without preeclampsia. DNA methylation, when a chemical group is added to DNA, can affect which genes are expressed. The researchers, while hopeful their test can find patients at risk for preeclampsia in time to prevent it, say more studies are needed to confirm their findings.



Closer Look

Opinion: From hospitals to the halls of Congress, advance directives have a role to play

GettyImages-1556768359Drew Angerer/Getty Images

We're all familiar with advance directives, in which people state their wishes for their care when they can no longer speak for themselves. The law formalizing this process in hospitals arose after a Supreme Court decision about a young woman who was left in a permanent vegetative state after a car accident. Justice Sandra Day O'Connor's opinion lamented that Nancy Cruzan had not formally expressed her preferences for life-sustaining therapy in advance.

What if there were directives not just about the end of life but of political service? "As a physician I have seen medical care continue too long when burdens outweigh any hope of benefit," medical ethicist Joseph Fins writes in a STAT First Opinion. "And recently, as a citizen watching Sen. Mitch McConnell's 20-second freeze and Sen. Dianne Feinstein's alarming committee meeting, I have seen distinguished careers that may have gone on for too long." Read more on his solution.


health

Study documents brain damage in young athletes

In a brain bank study of athletes who played contact sports and died before their 30th birthdays, evidence of brain injury was found in 41.4% of them, a new paper in JAMA Neurology reports. Nearly all of the 63 out of 152 players had early stages of chronic traumatic encephalopathy, a condition Boston University researchers have linked in professional athletes to repetitive head impacts. The new work confirms that CTE can occur in young athletes, too, including the first woman diagnosed, a 28-year-old college soccer player. Other sports included American football, ice hockey, soccer, rugby, and wrestling.

Brain bank studies don't represent the wider population (donations are made because brain damage is suspected). The young people also had such issues as depression (70.0%), apathy (71.3%), difficulty controlling behavior (56.8%), and problems with-decision making (54.5%). Suicide was the leading cause of death, followed by drug overdose.


Infectious disease

CDC: Risk of malaria in the U.S. 'remains very low' 

A week and a half ago, a single case of locally acquired malaria was reported in what's known as the National Capital Region of Maryland. That attracted attention because most cases arise another way: imported into the U.S. by people traveling from countries with malaria transmission, many in sub-Saharan Africa or South Asia. Before this year's Maryland example, locally acquired mosquito-borne malaria had not been detected since 2003.

Yesterday the CDC updated cases of local transmission in Florida and Texas unrelated to the Maryland one. Florida has identified seven cases and Texas has identified one case of locally acquired P. vivax malaria, but there have been no further reports of local transmission in Florida or Texas since mid-July. "The risk to the U.S. public for locally acquired mosquito-transmitted malaria remains very low," CDC said, but health care providers are advised to be alert for patients with high fevers, chills, headache, muscle pain, and fatigue.


More around STAT
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What we're reading

  • As competition looms, Insulet sues a rival for stealing trade secrets on diabetes tech, STAT
  • Opinion: A fitting final gift from Jimmy Carter, New York Times
  • A broad genetic test saved one newborn's life. Research suggests it could help millions of others, Associated Press
  • 'Despair is settling in': Female suicides on rise in Taliban's Afghanistan, The Guardian
  • FDA delays enforcement of a pharmaceutical supply chain law by a year, STAT
  • Opinion: How the twin crises of climate change and poor public housing are harming people's health, STAT

Thanks for reading! More tomorrow,


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