Breaking News

Ketamine treatment out of reach, advanced early embryo models, & an 'honest, funny man' battles addiction

September 7, 2023
Reporter, Morning Rounds Writer
Good morning. Two compelling tales from STAT contributors: One tells us that finding a treatment for suicidal thoughts doesn't mean it's easy to get, and the other travels with someone battling opioid addiction in a neighborhood known for "tranq."

mental Health 

Ketamine can be transformative for people with suicidal thoughts, but it's out of reach for many 

Marisa Russello has her blood pressure read before receiving an IV infusion of ketamineDana Ullman for STAT 

Marisa Russello (above) was overwhelmed by suicidal thoughts. Every day. She starting thinking about about suicide when she was 12, was diagnosed with bipolar disorder when she was a teenager, and attempted suicide in 2016. After enduring several hospitalizations and so many drugs that failed to help her, she was searching for a solution when, at age 33, she found ketamine in 2019. 

It worked. The daily suicidal thoughts vanished. "I was shocked," she said about her second treatment. "It was like [they were] siphoned out of my brain. Ketamine was a miracle." While IV ketamine doesn't work for everyone and therapy and other drugs may still be needed, it can be transformative. But the roadblocks erected by insurers unwilling to pay for ketamine and the distances some people must travel to get it means some people must choose between their health and financial uncertainty. STAT contributor Emily Malone has more. 


If you or someone you know may be considering suicide, contact the 988 Suicide & Crisis Lifeline: call or text 988 or chat 988lifeline.org. For TTY users: Use your preferred relay service or dial 711, then 988.


in the lab

Most advanced early human embryo models created from stem cells

A stem cell–derived human embryo model at a developmental stage equivalent to that of a human embryo at day 12Jacob Hanna/Weizmann Institute

Scientists in Israel have created stunningly lifelike lab versions of early human embryos made entirely from stem cells and grown outside the uterus. As STAT's Megan Molteni wrote earlier this summer, the team from the Weizmann Institute coaxed their dish-bound "embryo models" to develop up to a point equivalent with day 14 of a human pregnancy. In now-published research in Nature, they detailed the complex 3D structures these ersatz embryos organized into — including precursors of the placenta, yolk sac, and other external tissues crucial to further growth and development (above). 

The advance promises to help researchers peer into the difficult-to-study first weeks of embryonic development — when most miscarriages happen and many birth defects originate — to better understand the ways in which development can go wrong. The field of "stembryology" is moving so fast that researchers recently proposed a new definition for embryos that includes ones made in a dish from stem cells — should they one day become close enough to the real thing. 


STAT future summit

The future of cancer therapy looks bright — if more people can get it

In the decade since CAR-T cancer therapy was introduced, its success in treating cancer has allowed people to utter the word "cure" for up to 7,000 patients. It's a rigorous process to remove cells from their bodies, engineer them to fight cancer, and then reinfuse them. There have been serious backlogs in manufacturing these bespoke treatments, making off-the-shelf approaches more attractive, if more challenging to develop. 

"The focus really has to be on how to make the treatment more patient-friendly and addressing patient access so that the field can continue to grow and help as many patients who are out there in need of the treatment," Allogene Therapeutics CEO David Chang said yesterday during a panel on CAR-T's future at the 2023 STAT Future Summit.

There are other barriers to advances in cancer care. "We're talking about early detection of cancers, multi-cancer early detection sort of approaches are happening. Where are the discussions of how these get out to the rural communities? The at-risk, underserved communities?" Robert Winn of Virginia Commonwealth University asked at another panel. "I'm trying to ring the bell of awareness that as we are making these leaps and bounds within the medical sciences, we also really pay close attention to making sure the distribution of these miracles is more equitable."



Closer Look

How a 'good, honest, funny man' battles addiction

Shaun Anderson rides the subway with friends in May, one day after moving into an apartment found with the help of a social services organization, Prevention Point. Rachel Wisniewski for STAT

Shaun Anderson (above) lives in Philadelphia's Kensington neighborhood, thought to be the largest heroin market on the East Coast. It's also reputed to be where xylazine, the animal sedative known as "tranq," seeped into the illegal drug supply almost a decade ago. It's definitely where Anderson struggles every day with opioid addiction. "All I ever wanted was to be a good husband and father. … Heroin mess[es] with you. I forget who I am — which is a good, honest, funny man."

STAT contributor Rachel Wisniewski followed Anderson over several months, hearing his story and photographing his world as he regained housing and learned again what it's like not to sleep out in the open, fearful of getting beaten up. He's working with a case manager, someone who's in recovery herself, someone who knows that for many like Anderson who resolve to quit, it's far easier said than done. Read more.


pandemic

Health insurer says more people over 65 are in the hospital for Covid

More older adults have been hospitalized for Covid-19 over the past several weeks, according to internal data reviewed by health insurance giant Humana. Most of the insurance coverage the company provides is for people 65 and older, the same group of people more vulnerable to Covid's most severe effects. Humana did anticipate more Covid cases, but not in the summer.

In June, Humana said it was recording higher medical claims costs because its insurance members increasingly were going to emergency rooms, getting outpatient surgeries, and seeing dentists. Its new disclosure of more Covid hospitalizations was not a major factor in that jump of health care use, but Covid cases have been on the rise in the U.S. and around the world as infectious disease experts track new subvariants of the virus, which has not yet fallen into a seasonal pattern like other respiratory diseases. STAT's Bob Herman has more.


health

There are gaps to be filled in menopause science

After 70 years of research, you'd think we might know more about menopause. But a new review in Cell of that time span calls out research gaps while urging individualized treatment for women (a term they use to reflect existing scientific literature while acknowledging others may go through it). The authors set the tone this way: "Recognition that menopause, for most women, is a natural biological event, does not exempt the use of interventions to alleviate symptoms."

Those symptoms can be temporary, like short-term memory loss, or severe, long-lasting, and silent, such as bone loss and a higher risk of diabetes, cardiovascular diseases, and certain cancers. Few treatments besides hormone therapy have been well researched, and even that treatment is far from a perfect solution for all patients. The authors recommend individualized therapy that takes into account age and health risks as well as expanding research beyond high-income countries.


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