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A new Chan Zuckerberg biohub, helping older people in a warming world, & FDA's struggle to regulate food

October 19, 2023
Reporter, Morning Rounds Writer

Good morning. This is totally unscientific, but I submit that when Lotte Knudsen took the stage at the STAT Summit yesterday, more iPhones were whipped out on the balcony overlooking the stage than for any other speaker (with the possible exception of virtually present Mark Zuckerberg and Priscilla Chan). Just before she was named the recipient of STAT's 2023 Biomedical Innovation Award, here's what Knudsen said about developing weight loss drugs based on the peptide GLP-1:

"I was always the one saying don't forget about GLP-1 and challenging decisions at the company, but we moved on," she said. "Often with science ... the science that really translates and it's reproducible, it's the work of many people that do different things that complement each other." STAT's Elaine Chen has more. Read on for more Summit news.

stat summit

Exclusive: A new CZI Biohub aims cellular machines against disease

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STAT

Here's a Summit scoop: Meta founder Mark Zuckerberg and his wife, pediatrician and philanthropist Priscilla Chan, announced yesterday they plan to invest $250 million over 10 years to establish a new "biohub" in New York City focused on building a new class of cellular machines that can surveil the body and snuff out disease. It's the latest program from the Chan Zuckerberg Initiative, founded in 2015 to help cure, prevent, or manage all disease by 2100. 

The new hub, bringing together Yale, Columbia, and Rockefeller researchers, joins a Chicago Biohub where researchers will try to use tiny devices to decode how immune cells go wrong and create inflammatory disease. The New York hub will study what goes right. "When you first read it, it does feel like, 'is this a 'Fantastic Voyage?''' Chan told STAT's Jason Mast, citing the 1966 film in which a submarine crew is shrunk down to repair a scientist's injured brain. Read more


stat summit

Wait, there's more: Lessons from the pandemic and nerdiness at home

STAT Executive Editor Rick Berke asked Zuckerberg if he'd learned any lessons about scientific misinformation during the pandemic. "The pandemic was really tough on this, and I think it eroded a lot of people's trust in science, which was tough. I think both because of some of the misinformation that got out, as well as some of the things that authorities claimed were absolutely the truth, which ended up being wrong," he said. "This is one of the most challenging parts of running a social network company at this point [...] getting the balance of free expression."

On a lighter note, Zuckerberg characterized the Summit crowd as "science nerds." Chan went further, saying they're both members of the club. "We cannot one-up each other on nerdiness in our household," she said. "Just imagine what our children are like." Zuckerberg's response: "We love awesome things. What biology is on the precipice of is a lot of awesome things."


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'It's hard. It's very hard': John Maraganore's advice to budding biotech entrepreneurs

You could call him an elder statesman for biotech entrepreneurship. As founding CEO of Alnylam, John Maraganore took a promising but unproven approach for treating genetic disease — RNA interference — and built a new class of medicines and what is now a nearly $21 billion company. Since stepping down in 2021, Maraganore has been passing down his knowledge to up-and-coming biotech CEOs. 

He shared some of that wisdom yesterday at the 2023 STAT Summit, at a time when companies are struggling in what he called the worst environment for capital formation in biotech history. And yet, "it seems like every Ph.D. graduate student wants to be the CEO of their graduate thesis company. I think that's a little bit crazy," he said. "If my child asked me what to do, I'd say, 'Spend 10 years learning drug discovery, learning drug development before you do anything on your own. Because it's hard. It's very hard.'" STAT's Jonathan Wosen has more.



closer look

Building better homes for older people in a warming world

 

Think back to this past summer, when heat waves affected people around the world. Older adults are particularly vulnerable because their bodies can't perceive heat or deal with it as well as younger people — a growing problem as climate change worsens. Helping older people better cope with heat in their own homes is the mission of engineer Amir Baniassadi, who was recently named a STAT Wunderkind.

A postdoc at Harvard, Baniassadi works with doctors, architects, and engineers to assess heat vulnerability and how buildings could be constructed to mitigate risk as global temperatures rise. His work explores a network of variables that affect a person's exposure to heat or cold, including their socioeconomic status, cognitive function, and personal history. "This is a new reality," Baniassadi said. "There are people who are going to be hurt. How do we make them hurt less?" STAT contributor Allesandra DiCorato has more.


politics

Biden's nominee to lead NIH takes the middle road

In her long-delayed confirmation hearing, NCI Director Monica Bertagnolli, President Biden's nominee to lead the NIH, walked a middle road between Republicans and Democrats on hot-button issues like drug pricing and gender-affirming care. "I myself believe that the American people deserve a fair return on the investment that Congress has placed within the National Institutes of Health and the research that we do, and I will commit to working to make sure that the benefits of our research are affordable and available to all the American people," she said. 

Speaking in general on the health of LGBTQ+ people: "We have the greatest responsibility to ensure two things. First, that we serve all people, people of all walks of life, and that we really are here to achieve the health of all; but that number two, any research that we do that involves human beings, people, is conducted according to the highest ethical principles," she said. STAT's Sarah Owermohle has more, including an update on Bertagnolli's cancer treatment.


health 

How the FDA struggles to regulate food

Have you ever heard of brominated vegetable oil? Here's some perspective: Richard Nixon was president when the FDA first warned that the food additive could harm the liver, the heart, and other organs. The FDA finally sent a proposed ban to the White House this past August. Meanwhile, brominated vegetable oil has been illegal in the U.K. since 1970. 

STAT's Nicholas Florko tells us the story of brominated vegetable oil to highlight what for food safety advocates has been a decades-long struggle to get regulators to take quicker, more decisive action on food additives that raise safety concerns. Red Dye Number 3 is another example of the long road to action. The acting director of the FDA office charged with reviewing food additives did acknowledge to Nick that the office could be more efficient with greater funding, but in the case of brominated vegetable oil, it took new studies to prompt the agency recent action. Read more.


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What we're reading

  • The latest college campus freebies? Naloxone and fentanyl test strips, NPR
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  • Pfizer prices Covid drug Paxlovid at $1,400 for a five-day course, Wall Street Journal
  • Amazon will start testing drones that will drop prescriptions on your doorstep, literally, Associated Press
  • Biotech investors push to extend time before pills are subject to price negotiations, STAT

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