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An encouraging sign for xenotransplantation, the new country doctors treating rural America, & a plan for rare diseases

October 12, 2023
Reporter, Morning Rounds Writer
Good morning. In the second installment of STAT's "Treating Rural America" video series, watch physicians in a family medicine residency program in Selma, Ala., designed to meet an urgent need in underserved communities.

Health

CRISPR-edited pigs kept monkeys alive 

A gene-edited Yucatan minipig.

Liz Linder, courtesy of eGenesis

Developing pig organs that are safe for transplant into people is the ambition of the long-struggling science of xenotransplantation, a goal aimed at helping the roughly 17 people who die each day in the U.S. while waiting for human organs. The field notched a win yesterday, noting in Nature that an engineered breed of miniature pig containing up to 69 genetic changes produced kidneys that functioned well in monkeys for an average of 176 days and in one animal for more than two years.

The pigs are a project of eGenesis, co-founded by renowned Harvard bioengineer George Church and one of his protegés, Luhan Yang. "We now have a donor that we believe has a reasonable chance of success in the clinic," eGenesis CEO Mike Curtis told STAT's Megan Molteni. That move won't be immediate, at least not in the U.S., but it may be closer in Japan. Megan explains that, and more.


covid-19

Not enough children are getting their Covid vaccinations, experts warn

Far too few children are being vaccinated against Covid-19, vaccine experts warned yesterday in a panel discussion hosted by the National Foundation for Infectious Diseases and the Covid-19 Vaccine Education and Equity Project, STAT's Helen Branswell reports. The effect, one said, is eroding the amount of immunity against the disease in the community, increasing the risk for both the children and the people they come in contact with.

Roughly 10,000 children a day become eligible for Covid vaccination as they hit the age of 6 months, but only about 7,000 children a week under the age of 4 are being vaccinated, said Michelle Fiscus, chief medical officer for the Association of Immunization Managers. Fiscus acknowledged that finding medical practices that stock pediatric Covid vaccine doses is challenging in parts of the country, as the commercial market takes over what had been until this fall a federal government delivery program. "There are plenty of parents out there who are ready and willing to get their children vaccinated, but can't find a vaccine for those young children right now," Fiscus said.


medicine

Academic surgery leadership is 'conspicuously nondiverse,' study finds

An analysis published yesterday finds leadership within academic surgery remains "conspicuously nondiverse" despite the fact that a diverse medical workforce is known to improve patient care, STAT's Usha Lee McFarling tells us. The JAMA Surgery study of more than 146 medical schools in the U.S. and Puerto Rico conducted in the first half of 2022 found that white males were far more likely to hold leadership positions than others and that women and people from groups underrepresented in medicine hold less than 9% (192) of all leadership positions.

Even in the field of obstetrics and gynecological surgery, a rare field that includes high numbers of women, most chairs were male. The study identified no American Indian, Alaska Native, Native Hawaiian, or Pacific Islander chairs of surgery. 

When women and people from underrepresented groups were in leadership, the study found they were most likely to be in lower positions such as vice chair or division chief and were most likely to oversee areas such as DEI or wellness — positions that may not have a clear path to advancement and may, the authors wrote, "represent roles with low, rigid ceilings and limited mobility … at best unwitting and at worst insincere methods for promoting URiM and female surgeons while ultimately limiting their potential to become chairs of surgery."



Closer Look

The new country doctors treating rural America

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STAT

Before going through her family residency program at the University of Alabama in Selma, physician Olusunmisola Oyesiku always thought she would practice in a big city, but then she ended up falling in love with rural medicine. "Being exposed to that wide diversity of care made me realize that, you know, this could actually be more fulfilling and rewarding for me in my medical career than if I had stuck to one other specialty and just done one thing for the rest of my life," she said.

Doctors like Oyesiku are needed in critically underserved rural communities. Multiple studies have shown that physicians who train in a rural area are much more likely to stay and practice in a rural community. There are now more than 160 accredited rural training programs according to The RTT Collaborative, a cooperative of rural residency programs. Watch the second installment of our rural health series from STAT's Hyacinth Empinado.


drug development

How a top FDA official thinks the agency could jump-start gene therapy businesses

Peter Marks, a top official at the FDA, wants to reinvigorate the gene therapy field through more accelerated approvals and a closer working relationship between regulators and companies. "We're not here to be like consultants. But at the end of the day, some of what we do is the functional equivalent of consultants, right?" he told STAT's Jason Mast. He has nicknamed a new agency initiative "Operation Warp Speed for Rare Disease." And he encourages questions from biotechs. 

"I think my initial advice will be the same thing as my seventh grade history teacher, which was there is no question that is too stupid," he said, recalling his own experience on biotech's side of the table. "If it's on your mind, you should ask it. Because oftentimes questions that seem like they may not be the smartest, sometimes are the ones that have remarkable insight." Read the full interview.


health

Risk factors for dementia — the modifiable ones —vary by racial and ethnic group

Changing some health conditions can lower the chances of developing dementia. Eliminating hypertension, obesity, diabetes, low HDL ("bad") cholesterol, and sleep disorders could cut the risk by 40%. But a new study in PLOS One found that these factors pose more risk for some people than for others. Data from more than 850,000 people in England showed that while more white people (16%) developed dementia over the study's 20 years than South Asian people (9%), Black people (12%), and other ethnic groups (10%), the same risk factors often conferred a higher risk of dementia in Black and South Asian people, particularly for cardiovascular risk. 

It's another reminder that most dementia research has focused on people of European descent. It also explains the greater susceptibility, earlier age of dementia onset, and shorter survival after dementia diagnosis in certain ethnic groups. The authors urge prevention efforts that take these differences into account, including access to care.


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What we're reading

  • New A.I. tool diagnoses brain tumors on the operating table, New York Times
  • Medicare may plan to negotiate drug prices, but some states are taking their own steps to lower costs, STAT
  • Abortion tests' developed in Poland spark concern, Nature
  • Humana CEO Bruce Broussard to step down next year, STAT
  • NASA finds signs of the 'building blocks of life' in sample brought back from Bennu asteroid, El Pais
  • Major biomedical research funder Wellcome Trust names Røttingen as its new CEO, STAT

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