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Helen Branswell on China’s surge in respiratory disease, upside-down biotech job market, & thick thighs save knees

November 27, 2023
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Reporter & Podcast Producer
Okay everyone, I actually crushed it at the turkey trot by coming in first place out of my four immediate family members (very far from first place overall). I hope you're feeling rested and ready to dive into the news as we begin the final sprint toward the end of the year.

PUBLIC HEALTH

What to know about China's surge in respiratory disease

ICYMI: The World Health Organization and Chinese health officials convened via a conference call on Thursday last week as the global health agency sought information about reports of increases in respiratory illnesses among children in China that have put disease watchers elsewhere on alert. The Chinese explanation — one that the WHO appears to have accepted — is that while respiratory disease activity in parts of the country is at high levels among young children, the illnesses are caused by known pathogens, STAT's Helen Branswell reported.

After the meeting Thursday, the WHO said it would continue to monitor the situation, and urged other countries not to impose travel restrictions on China. On Friday, Helen spoke with Maria Van Kerkhove, the acting director of the WHO's department of epidemic and pandemic preparedness and prevention, for more details. Here's a snippet of what she said:

WHO asked China for surveillance data but also for laboratory results. What kind of evidence did you get that what they're seeing is what they told you they were seeing?

What they were giving us was an overview of current trends in acute respiratory illnesses across the country. And they were giving us some readouts from that surveillance system based on age. They also gave us a readout on a new multiple pathogen surveillance system that started in mid-October looking at 13 pathogens.

Why do you think this sort of blew up in the last few days?

You hear "undiagnosed." People think, well, that means they must have ruled everything else out, and therefore it's probably new. You hear "clusters," which means there's some people linked in space and time. "Children" — which is always alarming — "with pneumonia," which indicates a level of severity. And you hear "China." So I think a lot of people were immediately drawn back to the beginning of the Covid pandemic and thought: Oh God. Not again.

Read the full conversation.


biotech

Biotech's upside-down job market

biotech-job-market-blue-bright

Christine Kao/STAT

As any listener (or producer) of The Readout LOUD knows, the biotech industry has gone from what some observers called a "sugar high" to a downturn that is making it difficult for both public and private companies to raise money. More than 100 companies laid off employees in the first half of 2023, according to the industry trade group BIO, which is double the pace of the prior year.

There's also a dramatic decline in the number of open positions. "A good candidate in 2021 had five or six offers in hand," Adam Kaner, a senior vice president at the life sciences recruitment firm PharmaLogics, told STAT's Jonathan Wosen and Damian Garde. "Now the market has flipped completely from a candidate-driven market to what is definitely more of an employer-driven one." One Ph.D. graduate told STAT that she has applied for more than 53 positions (and counting). Read more on the unexpected trials for biotech job applicants.


environmental health

What's the relationship between environmental toxins and chronic disease?

Nearly a decade on, the Flint water crisis still looms large in the minds of the public. It was — and continues to be — evidence that not all communities in the U.S. are equally affected by environmental pollutants. And the stakes are high: New research suggests a link between Black Americans' higher exposure to environmental toxins and advanced liver scarring, which can lead to disease and cancer.

Researchers looked at blood samples of 43,000 Americans included in the National Health and Nutrition Evaluation Survey, and compared the results to the pool of people who had metabolic dysfunction-associated steatotic liver disease (previously called nonalcoholic fatty liver disease). They found that African American participants' liver scarring was strongly associated with their blood level of lead. While the study, presented at The Liver Meeting earlier this month, doesn't prove low-level exposure to environmental toxins causes liver damage, it highlights a growing theory among some researchers: That our chronic disease epidemic might be driven at least in part by the very environments we inhabit. Read more about the research from STAT's Isabella Cueto.



public health

Bringing better health care to Kenya's informal settlements

IMG_4786CFK Africa 

Jeffrey Okoro had only lived in Kibera — Kenya's largest informal settlement on the outskirts of Nairobi — for 15 minutes when he was arrested by a police officer there. But despite developing a chest infection and bloody, watery bowel movements within days, he remembers going years without seeing a real doctor. Now, more than 20 years later, Okoro is the executive director of CFK Africa, which works to improve public health and economic prosperity in informal settlements in Kenya through integrated health and youth leadership initiatives.

"Health care is a privilege in Kenya, especially for residents of informal settlements who often get into debt to receive some of the most basic health care services," Okoro writes in a First Opinion for STAT. "When I think back to how I came to this point, it seems remarkable that I made it this far." Read more from Okoro about his youth in Kenya and how he wants to make sure young people today receive better health care than he did.


health

Study says: Thick thighs are a prize

After dominating my immediate family in this year's turkey trot, I was pleased to see new research that says stronger quad muscles (at the front of the thigh), relative to the hamstrings (in the back), may lower the risk of a total knee replacement. Researchers looked at MRI data from 134 participants in the Osteoarthritis Initiative, a nationwide study sponsored by the National Institutes of Health. Half of the participants received a total knee replacement and were matched to those who hadn't, based on measures like age, gender, BMI, and more. A higher ratio of quads to hamstring volume was associated with strongly reduced odds of a total knee replacement. Higher volume of hamstring muscle generally was also associated with lower odds of the surgery.

The study, which will be presented today at the annual meeting of the Radiological Society of North America, focused on people with arthritis, but researchers believe the findings could be relevant for the broader population. More prevention measures could be key, as knee replacements are currently one of the most common and expensive procedures in the U.S.


More around STAT
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Read premium in-depth biotech, pharma, policy, and life science coverage and analysis with all of our STAT+ articles.

What we're reading

  • The truth behind all that cortisol talk, The Cut
  • Hospices can't handle the growing number of patients who need wound care, STAT
  • How one rabid kitten triggered intensive effort to contain deadly virus, Washington Post
  • Antitrust lawsuit alleges UnitedHealth's Optum pressured a California hospital to stop competing over physicians, STAT
  • When the neighbors are all older, too, New York Times

Thanks for reading! More tomorrow —Theresa


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