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NIH's All of Us data effort gets a boost

November 2, 2023
Health Tech Correspondent
Good morning health tech readers! You're a bunch of health experts, right? What's the clinical term for a two-day candy hangover? Reach me with remedies and tips: mario.aguilar@statnews.com

Finance

VCs want to buy hospitals. Can they be better stewards than private equity?

Venture capital giant General Catalyst's plan to buy a health system as a playground for innovation made big headlines and seems to come with all of the right intentions/buzzwords: Health care transformation! Health assurance!

As my co-author Mohana Ravindranath writes, one of our existing models for how such acquisitions play out is private equity firms buying distressed hospitals. More often that not, they attempt to make the hospitals profitable by boosting revenue and streamlining operations, sometimes at the expense of clinical care. While VC outfits tend to have longer time horizons and more tolerance for risk than PE firms, it's unclear how that might apply to buying hospitals — and what might happen when pressure for returns ramps up.

For its part, General Catalyst has said its plan is a long-term bet.

Read more here


Research

All of Us gets a boost from real-world data

All of Us, the federal research program that promised to propel precision medicine forward with data from at least 1 million diverse Americans, is expanding its approach to collecting health data. Most of the program's information comes directly from participants, who share everything from their genetic sequences and survey answers to wearables data and electronic health records.

But STAT's Katie Palmer reports, there are still significant gaps — and with a new $30 million award to establish a Center for Linkage and Acquisition of Data, the program thinks it can siphon up more real-world data and match it to their participants while preserving their privacy. "If we really want to realize the promise of precision medicine and public health — evidence-based decision making for both — we've got to put the patient back together again," said Melissa Haendel, the new center's leader. 

Read more here


DIY

3D printing tourniquets in Gaza

20220408_122627-768x432Aside from the stethoscope, the around 20-person Glia team manufactures tourniquets, ear otoscopes, and caps to stop bleeding in dialysis patients.

Tarek Loubani looked around at his fellow doctors at Al Shifa Hospital in Gaza City and realized he held one of just two stethoscopes in the room.

It was 2012, and he was treating patients injured during the recent clashes between Israel and Palestinian groups. Without stethoscopes, providers knelt down to patients' chests to check if they were breathing. Loubani, an emergency room physician in Canada and Kuwait-born Palestinian refugee who regularly works in Gaza, wondered how health care workers could manage without one of medicine's most basic tools.

STAT's Lizzy Lawrence reports that the stethoscope became the inaugural device of the Glia Project, a group founded by Loubani in 2016 that 3D prints open-source medical equipment for low-resource areas. Loubani grew the organization with the help of Carrie Wakem, a former hospital colleague who now serves as Glia's executive director. The tiny group is pioneering a bold new vision for democratizing medical devices, starting in war-torn areas where they're most needed.

Read more here



Artificial Intelligence

DeepMind's new skills

This week Google DeepMind and its drug development spinoff Isomorphic Labs announced significant updates to their AlphaFold model, which predicts the structures of proteins using just their amino acid sequences. Now, they say the AI model can predict more complex structures as proteins interact with a wide range of molecules, making it more powerful for drug discovery. "We can and we are applying this today to our internal programs and day-to-day drug designs," Max Jaderberg, Isomorphic's head of machine learning, told STAT

But they're not the only ones pushing protein folding forward: Three weeks before Isomorphic dropped the news, a competing lab at the University of Washington published their own model update. Read more about the rivalry — and what it could mean for these models' use in research and the pharma industry — from my colleagues Katie Palmer and Brittany Trang.

Read more here


More around STAT
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What we're reading

  • I went to paradise to see the future of AI, and I'm more confused than ever, The Verge
  • Some deaf children in China can hear after gene treatment, MIT Technology Review
  • Health automation company Olive AI is shutting down, Axios
  • CEO of Ozempic prescription startup Calibrate steps down as investors eye 'rapid downsizing' of consumer business, Fortune

Thanks for reading! More on Tuesday - Mario

Mario Aguilar covers how technology is transforming health care. He is based in New York.


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