Breaking News

Ripples from Idaho abortion case, a treatment for menopause, & making ERs safer

January 10, 2024
Reporter, Morning Rounds Writer
Good morning. It's been a while since we've had not one, but two news items on Covid-19. It's still here and we're still learning.

reproductive health

Supreme Court's Idaho decision may spur abortion bans in other statesGettyImages-1243695901

Stefani Reynolds/AFP via Getty Images

Last week the U.S. Supreme Court agreed to hear a case on the legality of an Idaho abortion bill and reinstate its restrictive ban while it decides. That may be a harbinger of change in other states, lobbyists and anti-abortion groups told STAT's Olivia Goldhill and Annalisa Merelli. At issue is an Idaho policy permitting abortion only to prevent the death of the mother, which the Biden administration argues does not comply with the federal Emergency Medical Treatment and Labor Act.

The case highlights ongoing confusion over what constitutes a medical emergency and legally permissible abortion. States "don't want their emergency rooms to be turned into abortion clinics," Carol Tobias, president of the National Right to Life Committee, said. Rabia Muqaddam, senior staff attorney at the Center for Reproductive Rights, said, "We have physicians saying, We want to help these patients but our hands are tied because we don't know how to make decisions and the state has made threats." Read more.


biopharma

JPM gets rolling on gene therapy, 'digital biology,' and how hospitals can make money

Here are some of the latest updates from JPM 2024

  • Peter Marks, the FDA's top regulator of gene therapies, seems very comfortable with granting some form of full approval to Elevidys, the Sarepta Therapeutics gene therapy for Duchenne muscular dystrophy, based on his comments to STAT's Adam Feuerstein describing a "hypothetical case."
  • What JPM session drew a rapt audience of bankers, spilling out into the aisles and hallways? A presentation by Nvidia, the chipmaker with a market capitalization that's soared beyond $1 trillion for its role in artificial intelligence. Nvidia's vice president of health care Kimberly Powell described why the company thinks AI, running on Nvidia computers, could dramatically increase the number of new medicines created while reducing their cost, ushering in an age of "digital biology." STAT's Matthew Herper explains.
  • If you learned anything about nonprofit hospitals so far at JPM, STAT's Tara Bannow tells us, it's that they've all but abandoned the prospect of making significant profit on patient care. Instead, they're fully throwing their weight into other ways of making money: developing drugs or selling insurance, aka "revenue diversification" in industry jargon.

Health

Bayer's experimental menopause drug would tap into growing market

Bayer's promising results in two late-stage trials for a drug to treat symptoms of menopause come just a few months after the market launch of Vezoah by Astellas Pharma. Both take non-hormonal approaches to relieving hot flashes, and Bayer says its drug candidate, elinzanetant, may also help improve sleep and quality of life.

Vezoah and elinzanetant haven't been compared in head-to-head trials, but if  elinzanetant wins regulatory approval, both would enter a global market that research firm Gran View estimates will reach $24.4 billion by 2030. "Menopause is turning into big business," Kelly Casperson, a urologist and menopause specialist, told STAT's Annalisa Merelli. "People quit their jobs because of unmanaged hot flashes." Read more.



first opinion

How an emergency doctor would prevent ER violenceAdobeStock_569658251

Adobe 

Health care workers are targets of violence at levels five times higher than in other professions. There is no more vulnerable place than the ER, where pretty much no patient wants to be. For staff, ER boarding of hospital patients and crowding require constant workarounds, draining their cognitive and compassionate reserves. Emergency physician Jay Baruch shares lessons he's learned about how patients' powerlessness and loss of control feed their aggression. 

To restore a measure of control to them, a quiet room, a lack of judgment, and an offer for medication if necessary work. But when ERs have no rooms (quiet or otherwise), Baruch writes in a STAT First Opinion, the goal should be not just safety, but security. "A respectful restoration of control is core to security, and control can feel elusive to ER patients as well as staff," he writes. "Folded into security is the belief that a thing or a place is fixed, reliable, and trustworthy." Read more on how to get there.


covid

Testing, testing, testing 

In my house over the December holidays, we broke out the Covid tests again, checking to see if that tickle in the throat was from an invading virus or a re-emerging cat allergy. There were negatives all around (and a Claritin fix), but were we too quick to assume we didn't have Covid-19? A story in the Los Angeles Times suggests we should have gone beyond the recommended repeat test at 48 hours (I know, I know) if we still had symptoms, and test again four days after the scratchy throats started (really?).

Why the need for so much testing? Elizabeth Hudson, regional chief of infectious diseases at Kaiser Permanente Southern California, points to accumulated immunity from Covid-19 over the past nearly four years, whether from vaccinations or previous infections. "It's actually pushing back the time that people's Covid tests are coming up positive," Hudson told the LA Times. "They should really, probably on Day 4, retest themselves if they're doing the home antigen test."


More covid

Study finds link between omnivorous eating and Covid — but hold off on overhauling your diet

Wouldn't it be nice if preventing Covid were this simple? A new study in BMJ Nutrition Prevention & Health suggests a plant-based diet might protect people against Covid-19 infection. The authors reached this conclusion after surveying 702 adults, nearly half of whom previously had Covid. Those who ate an omnivore's diet were more likely to have caught Covid (52%) than the herbivores (40%). Setting aside questions about how accurately people recall what they ate (a limitation the researchers acknowledge), skeptical readers might wonder about other factors that could explain the findings.

While there were no significant differences in sex, age, or vaccination status between the two groups, more people had postgraduate degrees in the group eating a plant-based diet. And meat-eaters reported a higher rate of medical conditions, including the known Covid risk factors of obesity and lower rates of physical activity. As Gavin Stewart of Newcastle University said in a statement, "The conclusion that plant-based diets have a preventative role in Covid-19 infection is premature and not warranted."


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What we're reading

  • How the VA fails veterans on mental health, ProPublica

  • Doudna institute hatches plan to 'cure hundreds of diseases' left behind by CRISPR revolution, STAT

  • GSK to acquire Aiolos Bio in $1.4 billion deal, picking up an experimental asthma drug, STAT

Thanks for reading! More tomorrow,


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