Startups
How an immunological Trojan horse could treat disease
For millions of patients with autoimmune diseases, the body's natural defenses errantly attack healthy tissues. One startup's plan to intervene involves disguising drugs as bodily trash and tricking the immune system into dragging that Trojan horse to its biological targets.
As STAT's Allison DeAngelis reports, the company is called Cour Pharmaceuticals, and it just raised a $105 million Series A round to flesh out its foundational idea. The technology involves using proprietary polymer nanoparticles to cloak molecules designed to sensitize the immune system. Once those nanoparticles reach the liver, the drug works like the inverse of a vaccine, telling the body to stop fighting against its own cells.
Cour is already in Phase 2 development with treatments for celiac disease and a rare liver disorder called primary biliary cholangitis. The company is also at work on treatments for type 1 diabetes and the neuromuscular disease myasthenia gravis.
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Washington
The Janet Woodcock exit interview
After more than three decades at the FDA, including a lengthy stint as its most powerful regulator of new drugs, Janet Woodcock is retiring from the agency and in the process ending an era.
Woodcock spoke to STAT's Sarah Owermohle for a wide-ranging exit interview, addressing the FDA's often tumultuous relationship with Congress, the agency's future in a changing society, and, of course, the ongoing controversy over which drugs deserve accelerated approval and which do not.
"I tend to look at results," Woodcock said. "What have been the results of that aggressive posture toward getting new cancer therapies — particularly targeted cancer therapies — out there to patients? Some people might say … there were some that didn't work out. Well, that's how accelerated approval is set up. Is that wrong? What's the alternative? You hold back all of these until you have definitive evidence? Based on the results, you would have a lot of people who wouldn't be alive. Was that worth it to have all that certainty?"
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Sequencing
The 'dark horse' startup with a $100 genome
More than a year after promising to roil the market for sequencing with a $100 genome, the privately held Ultima Genomics is launching a line of instruments meant to challenge Illumina's near-monopoly.
As STAT's Jonathan Wosen reports, the sequencer, called the UG 100, will cost $1.5 million and read up to 20,000 human genomes a year. Factoring in the cost of reagents, that works out to $100 per genome, according to Ultima, which plans to launch the sequencer at a scientific conference on Feb. 5.
The question for Ultima, and all of the many of the firms trying to unseat Illumina, is whether it can win over customers at the drug companies, hospitals, and research institutions that handle most of the world's genomic sequencing. The company has raised more than $600 million in venture investment since its inception, tapping a syndicate that includes Andreessen Horowitz and Khosla Ventures.
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