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Measles policy, IVF repercussions, & high-risk home births

February 23, 2024
Reporter, Morning Rounds Writer
Good morning. We bring you health writ large today, from measles policy to firearm deaths to the brain's "dysfunctome." 

Public health

Florida's 'choose your own adventure' policy during a measles outbreak alarms public health expertsGettyImages-495311747

Joe Raedle / Getty Images

There's a measles outbreak at a school in Florida's Broward County, but the state surgeon general is leaving it up to parents to decide whether to keep their unvaccinated children home. That flies in the face of standard public health policy, which aims to protect children who are especially vulnerable to the highly contagious disease. Measles has a long incubation period — up to 21 days — and can be transmitted up to four days before an infected person starts to feel ill. The county is offering online classes for those at home.

Six measles cases have been reported at the school in the past week. In a statement, Joseph Ladapo, the surgeon general known for questioning the safety of Covid-19 vaccines, cited high immunity levels in the community. Public health experts are taken aback. "It's really measles management 101," epidemiologist Katelyn Jetelina told STAT's Helen Branswell. "It's not really supposed to be 'choose your own adventure.'" Read more.


reproductive health

In Alabama, 'the next frontier after Roe v. Wade'

In the wake of an Alabama judge's ruling that embryos frozen for IVF treatment are children, many fertility clinics in the state have already paused their in vitro fertilization services, including the University of Alabama at Birmingham and Alabama Fertility Services. But Alabama is not alone: 11 other states also have fetal personhood laws, and in Alabama, Mississippi, Oklahoma, and South Carolina, pregnant women have been prosecuted under these laws for child endangerment and neglect.

Frozen embryos, as well as embryos that end up being lost because they aren't implanted, are necessary parts of IVF. "This is the logical end to the legal personhood movement, which we knew was going to be the next frontier after Roe versus Wade was overruled," said Seema Mohapatra of Southern Methodist University's Dedman School of Law. STAT's Annalisa Merelli has more.


pandemic

More than 134,000 cancers went undetected in 2020

We knew there would be fewer cancer diagnoses in the Covid-19 pandemic's first year, but we couldn't say how many. Fewer people sought out health care unrelated to Covid then, including cancer screenings or check-ups. A new analysis in JAMA Oncology estimates that more than 134,000 cancer cases were not diagnosed in the U.S. in 2020. To arrive at that number, the researchers looked at trends from previous years and then compared expected cancer rates for March through December 2020 with what was actually reported. 

Overall, cancer diagnoses were 13% lower than expected, with a 28.6% decline from March to May 2020 that was sharper in states with stricter stay-at-home rules. Among cancers with good screening tests, female breast cancer diagnoses returned to previous levels by June, but cervical, colorectal, and lung cancers did not. "With a near 10% reduction from expected rates in overall late-stage incidence from March to December 2020, there will undoubtedly — and unfortunately — be a subsequent rise in cancer mortality," the authors conclude.



closer look

No longer 'underground': high-risk births at home riseStat_2_16_2024

Maria Fabrizio for STAT 

High-risk home births "used to be really underground," Ida Darragh of the North American Registry of Midwives told STAT contributor Elizabeth Cohen, but that's no longer the case. While CDC data show home births make up less than 2% of all U.S. births, that rate is growing, including high-risk pregnancies. Three examples of high risk are vaginal birth after a previous Cesarean section, pregnancies in which the baby is not in a head-down position, and pregnancies with twins or other multiples.

"They can have some tragic complications and they're potentially avoidable with easy access to an operating room," said Sarah Little, a maternal-fetal medicine physician. But choosing a home birth may follow a bad hospital experience, especially for Black women, among whom home birth rates tripled from 2016 to 2022. "They're more choosing not to have that experience again than they are actively choosing to have a home birth," said Cassaundra Jah, executive director of the National Association of Certified Professional Midwives. Read more.


guns

This is how more children are dying from firearms

child-and-adolescent-firearm-death-distribution-vs.-population-distribution-by-race-and-ethnicity

KFF

Since the pandemic began, more children and adolescents under 18 have been dying from gunfire. That means seven deaths per day in 2022, a new KFF analysis of provisional CDC data calculates, exceeding car crash fatalities. Two-thirds of the deaths were from gun assaults, a jump from just over half in 2019. Other reasons included suicide, accidents, or unknown causes. The gap in gun assault death rates between Black and white children and adolescents has grown wider. Other differences:

  • Males were more than four times more likely than females to die by firearm, with rates rising by 50% from 2018 to 2022 among male children and adolescents while rates stayed the same among females.
  • Firearm death rates grew across the U.S. but vary by location: Louisiana, Mississippi, and the District of Columbia had the highest rates while Massachusetts, New Jersey, and New York had the lowest.

in the lab

Mapping the brain's 'dysfunctome'image002

Courtesy Barbara Hollunder

About 20 years ago, I watched what happened when deep brain stimulation was activated in a man with Parkinson's disease. He'd had electrodes surgically implanted as part of a clinical trial testing whether targeting malfunctioning brain circuits could ease his symptoms. In the exam room that day, his involuntary movements stopped, as if a switch had been flipped, and a smile slowly spread across his face. I thought of him yesterday while reading a paper in Nature Neuroscience demonstrating how deep brain stimulation can be used to study what the authors call the "dysfunctome" to understand what goes wrong not just in Parkinson's but also in dystonia, obsessive-compulsive disorder, and Tourette syndrome.

The researchers were able to map connections between brain regions that control cognitive and motor functions, and they looked at how electrical stimulation modifies these functions in 261 patients who'd previously had surgery to implant the electrodes. They identified specific brain circuits that had become dysfunctional in each of the four disorders, and they even fine-tuned treatment in one patient with Parkinson's disease and two patients with OCD based on their findings.


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What we're reading

  • Opinion: Ambivalence over AI: We are all Prometheus now, Undark

  • A hospital is suing to move a quadriplegic 18-year-old to a nursing home. She says no, NPR

  • DOJ investigating Community Health Systems' hospitals, STAT
  • Long Covid 'brain fog' may be due to leaky blood-brain barrier, study finds, The Guardian

  • FDA gives a mixed response to a petition seeking greater clinical trial transparency, STAT

Thanks for reading! More Monday,


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