Breaking News

Prominent oncologist faces lawsuit over research credit, Sanders' drug pricing theater, & promising data on RSV drug for infants

February 9, 2024
Annalisa-Merelli-avatar-teal
General Assignment Reporter

Buongiorno! A couple of juicy items in today's edition: A court case about an important scientific discovery and alleged attempts to derail its author's career, plus Sen. Bernie Sanders' high-production hearing on drug prices.

exclusive

"My career in research has just fallen off a cliff"  

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STAT/Adobe

Jamie Lin, a young nephrologist at MD Anderson Cancer Center, made important research findings in 2021 that could potentially save the kidneys of cancer patients and propel her career forward. But she alleges in a lawsuit that prominent oncologist Padmanee Sharma got in the way, derailing publication after pressuring Lin to add her as a co-author, even though she had not made meaningful contributions to the research. Sharma also reportedly threatened to withdraw funding offers for Lin's research as a retaliation.

"I'm sure that my career in research has just fallen off a cliff," Lin, who shared correspondence to support her claims, told my colleagues Angus Chen and Jonathan Wosen. More here.


pharma

Bernie's "prescription drug pricing theater" produces few answers

Despite much media attention, the Senate hearing on prescription drug pricing led by Bernie Sanders didn't bring about substantial new ideas to help patients pay less for prescription drugs, Rachel Cohrs reports

Sanders asked Bristol Myers Squibb CEO Chris Boerner whether he would commit to lowering US prices for anticoagulant Eliquis to Canadian levels. The CEO replied the difference between the two countries' pricing systems makes such a commitment impossible. Pharma executives answered questions about the drastically lower cost of drugs in other countries their usual talking points, like blaming middle men and highlighting the greater access to drugs that Americans enjoy. All in all, according to Sen. Mitt Romney, the hearing was largely about giving senators "an opportunity to pontificate on our various topics." More here.


addiction

Higher doses of naloxone don't increase overdose survival rates

People receiving double doses of naloxone are no more likely to survive an opioid overdose than people receiving a standard 4 milligram dose, according to a new paper from the Centers for Disease Control and Prevention.

This supports harm reduction groups' pushback against drug companies' marketing of expensive higher doses of naloxone as a way to counteract the effects of high-potency fentanyl, writes Lev Facher. The double doses both failed to impact survival rates and had harmful effects, more than doubling the incidence of withdrawal symptoms such as vomiting. Read more.



closer look

The case for banning menthol cigarettes

GettyImages-98149051-2Joe Raedle/Getty Images 
 

If Black Americans are more likely than any other group to die from tobacco-related disease such as diabetes and heart disease, much of the blame should go to menthol cigarettes, write former U.S. surgeons general Regina Benjamin and Jerome Adams in a STAT First Opinion. 

Menthol masks the harsh taste of tobacco in cigarettes, which is known to lead to increased smoking, and is the only flavor still allowed in cigarettes in the U.S. This is especially damaging to Black communities: about 80% of Black smokers use them, compared to 35% of white smokers. The solution, write the authors, is banning menthol altogether. Read more


health

RSV drug at least 70% effective in preventing hospitalizations among infants: Study

Early studies from Europe looking at the real-world impact of a new monoclonal antibody product to protect young children against RSV are showing promising results, STAT's Helen Branswell tells us. Data from Spain, published Thursday in the online journal Eurosurveillance, showed nirsevimab — sold as Beyfortus — was at least 70% effective at preventing RSV hospitalizations in infants under 9 months of age, the group at highest risk of developing severe disease. "These results predict a possible important impact of the nirsevimab immunization program on the high RSV disease burden," the researchers wrote.

An earlier article in Eurosurveillance showed that in Luxembourg, Beyfortus use led to a decrease in RSV hospitalizations of 38% in kids under age 5, and 69% in children under 6 months old in 2023 when compared to 2022. The researchers reported that children who did get hospitalized for RSV had shorter stays, and a smaller proportion needed to be admitted to intensive care.

Beyfortus is manufactured by AstraZeneca and commercialized by Sanofi, which was caught off-guard by the robust demand for the product in the U.S. last fall, leaving many families unable to find it for their young children. In a statement in December, Sanofi said it would "plan accordingly for next season."


reproductive health

Stricter abortion laws may mean fewer OB-GYNs

New research published in JAMA Network Open analyzed the number of applicants to OB-GYN training programs in states where abortion is severely restricted. The latest results are in line with previous research showing the impact of abortion bans on the prospective workforce: While the number of overall applications to OB-GYN programs remained stable between 2022 and 2023, states with abortion bans received fewer applications than those without them.

In 2023, about 82% of prospective ob-gyns applied in programs with abortion bans, compared with 86% in 2022 and 88% in 2021. (Almost 100% also applied to programs in states that protect abortion.) So far, the research found, this didn't impact the final matching results, and since all spots available tend to be filled, matches in states with bans were not different from those in states without bans. Still, the authors recommend following the application trends as a potential indicator of future OB-GYN shortages.


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What we're reading

  • Studies cited in abortion pill case are retracted due to flaws and conflict of interest, STAT

  • More adolescent boys have eating disorders. Two experts discuss why, The New York Times
  • Senate Democrats push for stronger rules around AI in Medicare Advantage, STAT 
  • A safe haven for late abortions, The New Yorker
  • Contact sports cause CTE. So why are Americans watching more football than ever? STAT

Thanks for reading! More on Monday — Nalis


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