Breaking News

Experimental pill blocked Ebola in early test, senators pressed Becerra on cyberattack, & and birds can stutter

March 15, 2024
Reporter, Morning Rounds Writer
Good morning. Read on for hopeful news from an early study of an Ebola antiviral in pill form and the latest word on what some advocacy groups want from the NIH. But don't miss the stuttering birds.

infectious disease

Antiviral pill against Ebola shows promise, study says GettyImages-1243482827

Badru Katumba / AFP via Getty Images

A new study in Science suggests the antiviral drug obeldesivir may be effective in curing a species of the Ebola virus known as Ebola Sudan, for which there are no approved vaccines or treatments. The researchers tested the drug in primates 24 hours after the animals got what should have been a lethal dose of the Sudan ebolavirus. Five monkeys given the drug survived, while two monkeys given a placebo died. Obeldesivir is a pill and in this study was taken daily for 10 days.

If the drug proves effective in people, it would be the first oral treatment for any ebolavirus. "I think it can definitely be a game changer," Tom Geisbert, senior author of the paper, said about the pill, which appears to be active against all known species of Ebola and a related virus, Marburg. STAT's Helen Branswell has more


medical devices

EPA restricts cancer-causing chemical used to sterilize medical devices

Almost a year ago, the EPA proposed new limits on ethylene oxide, a carcinogenic gas used to sterilize medical devices that can't be exposed to steam. Sterilizing facilities had polluted the air unchecked for decades, leading to disproportionately high cancer risks in surrounding communities. Yesterday, the agency finalized those rules, predicting a 90% reduction in emissions of the gas, which is more than the 80% cited in April 2023.

Ethylene oxide is now used to sanitize 20 billion devices in the U.S. per year, including pacemakers, catheters, and ventilators. But long-term exposure to the gas can cause breast cancer, non-Hodgkin's lymphoma, lymphocytic leukemia, and myeloma. In January, the FDA endorsed a safer chemical, vaporized hydrogen peroxide, but neither the FDA nor the EPA will require device makers to make the switch. STAT's Lizzy Lawrence has more, including expert reactions.


chronic disease

Advocates push for an NIH office to study post-infection chronic conditions

When the White House released President Biden's 2025 budget proposal this week, the figure for biomedical research funding was relatively flat. The odds of bumping up the request may be low, but that's not stopping some disease groups from trying. With their allies in research, advocates are pressing the administration to increase research funding and create a new body at the NIH to study chronic conditions that spring from infections.

Greater awareness of post-infection chronic conditions has been spurred by the recognition of long Covid, to which the RECOVER studies are devoted. Chronic Lyme, mast cell activation syndrome, Ehlers-Danlos syndrome, POTS, and myalgic encephalomyelitis/chronic fatigue syndrome, or ME/CFS, have received less attention. STAT's Isabella Cueto explains.



closer look

Songbirds can make new sounds. And they can stutterGettyImages-177397960

Patrick Pleul/DPA / AFP via Getty Images

For neuroscientist Erich Jarvis, the neural pathways he finds most interesting inside a birds' brain are those that enable the bird to make new sounds from listening to their environment. Known as vocal learning, it's the foundation of human language, too. He spoke recently with STAT's Nicholas St. Fleur.

From the neurobiological perspective, what is so fascinating to you about vocal learning in birds, and in us?

We have an extra brain pathway that controls our vocal organs and oral facial musculature for sound production that you do not find in other mammals or other birds like chickens. Spoken language is really a body movement pathway controlling the muscles of the larynx, producing all these interesting cognitive sounds and thoughts.

This research offers insight into disorders like stuttering. So birds can also stutter?

Vocal-learning birds can stutter, that's right. They will stutter with brain lesions in certain areas where the lesions in humans also cause stuttering.

Read the full interview (and listen to a bird stutter).


politics

HHS secretary gets an earful on fallout from Change HealthCare cyberattack

Patience is wearing thin on the Biden administration's response to a recent cyberattack that has frozen millions of hospital and physician insurance claims, senators told health secretary Xavier Becerra at a hearing yesterday. Senate Finance Committee Chairman Ron Wyden (D-Ore.) urged him to institute cybersecurity requirements for both hospitals and insurers and to "start holding these executives [accountable] who are not doing their job in line with the kind of safety standards Americans have the right to expect on cyber."

HHS has launched a probe of the attack, focusing on whether Change HealthCare and its parent company, UnitedHealth Group, complied with federal law protecting patients' health information. "Every sector within health care has to get into this, because no one could keep their data doors unlocked with these cyberattacks that are occurring," Becerra said. "We're trying to get the best information we can to know exactly how to proceed." Read more from STAT's Sarah Owermohle.


covid-19

Kids are still developing a rare inflammatory illness after Covid-19

Covid-19 cases may be falling, but an alarming side effect of the disease in children is still here.  Almost four years after the first cases of a condition called multisystem inflammation syndrome, or MIS-C, were reported, a CDC analysis published yesterday says cases are still occurring, especially among kids who are unvaccinated. MIS-C typically develops in the two to six weeks following SARS-CoV-2 infection. Marked by fever and inflammation of the child's heart, skin, GI tract, and other organs, MIS-C is rare but serious.

MIS-C incidence was highest in late 2020 and early 2021 but continued to rise in step with Covid case levels, as it did in fall 2023. More than 80%, or 92 of 112 MIS-C cases, were in vaccine-eligible but unvaccinated children. Among the 20 vaccinated children who had MIS-C, immunity had likely waned in 60% of those children by the time of their illness.


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What we're reading

  • The persistent mystery of protein intake, The Atlantic

  • Madrigal wins first U.S. approval for drug to treat liver disease MASH, STAT
  • Editorial: Misconduct's forgotten victims, Science

  • Vertex hits speed bump in getting CRISPR sickle cell therapy covered in U.K., STAT

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