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John Green on tuberculosis, Haiti’s health system “under siege,” & the power of positive childhood experiences

March 18, 2024
theresa-g-avatar-small - light bg
Reporter & Podcast Producer

Good morning! If this email seems to shine a little brighter in your inbox than it did last Monday, maybe it's because I leveled up as a STATian after winning our famed pie contest last week — with a galette, no less. I hope you find these newsy items just as appetizing.

public health

Novelist John Green speaks about his tuberculosis advocacy

JohnGreen_credit_MarinaWaters2016

Marina Waters

Last year, novelist, YouTube star, and 2024 STATUS List member John Green used his online platform to go after Cepheid and Johnson & Johnson, successfully pressuring these companies to lower the cost of their diagnostic and therapeutic treatment for tuberculosis. Last week, he announced the latest move in his quest to end tuberculosis — a public-private funding partnership with USAID and the Philippines. John spoke with STAT's Katherine MacPhail about the efforts.

What is your ultimate goal or dream for your TB advocacy?

The dream is to live to see a world where tuberculosis is no longer a public health threat. That's my dream. And there's no reason why we can't make it a reality. The only reason anyone dies of tuberculosis is because of failures of human-built systems. And so I really believe we can see a world without TB, or at least a world where no one dies with TB. 

What brought this mission to advocate for access to TB care into focus for you? 

The reason I think I've become obsessed with tuberculosis is because it's such a glaring example of global injustice. This is a disease that is curable, it's preventable. And yet, it remains the deadliest infectious disease in the world. And I didn't know that — even though I care a lot about global health and that is something that my brother and I have been learning about for the last 15 years. 

Read the full interview.


artificial intelligence 

With AI's use in health care on the rise, investors flock to security, privacy startups

Health leaders are racing to deploy generative AI products that can automatically transcribe doctor-patient conversations during appointments or churn through massive repositories of scientific research, but they're still flummoxed by how to measure the quality of these tools. Cybersecurity experts have warned that indiscriminately hooking third-party apps up to health system networks could expose sensitive data to hackers, and regulators and industry groups are rushing to set standards for responsible AI use.

Investors see an opportunity there, and they're starting to back startups that offer privacy and security services to bolster health AI products already on the market while they wait for crucial safety and privacy regulations to take shape. Silicon Valley venture giants and hospital corporate investment arms alike told STAT's Mohana Ravindranath that they're keen to build out a parallel ecosystem of startups focused on AI governance, compliance, and data security and privacy. Read more.


health care

Haiti's health system, long "under siege," is now in crisis

About a week ago, Haiti's government extended a state of emergency and nighttime curfew originally declared on March 3. The emergency is putting an already precarious health care system under severe strain, STAT's Nalis Merelli tells us. "I can't say that I have seen a crisis that bad [before]," said Réginald Fils-Aimé, a Haitian physician and senior director of strategic planning for Zanmi Lasante, a health care nonprofit. "The health system has been under siege for a long time … but this has really exacerbated in the last weeks."

The issues, he said, include a surge of gunshot wounds as well as a dramatic increase in sexual violence. Roadblocks challenge the movement of supplies — medications, fuel, lab equipment — as well as health care workers. Maternity care programs are under jeopardy, said Fils-Aimé, and lack of access to clean water and sanitation is raising fears of a resurgence of cholera, especially during the incoming rainy season. 

Blood is the other big emergency, said Lyndsay Bryson, Médecins Sans Frontières' health adviser for Haiti. All health facilities rely on the same test center in Port-au-Prince, which has all but ran out of reagent to test blood quality, which exacerbates a shortage of donor blood. "In a context where trauma is quite a big challenge, you need blood," she said. "And this is something that's been quite problematic for sure."



drug pricing

CVS's new ploy as Humira biosimilars take over the market

CVS-rebate

Christine Kao / STAT

Pharmacy benefit managers, or PBMs, are the middlemen of drug pricing negotiations and wrangle discounts out of pharmaceutical companies for their clients. But PBMs also claim portions of those lucrative rebates for themselves. So when new market developments threaten to diminish or wipe away that revenue stream, PBMs find crafty ways to keep as many of those dollars as possible — often at the expense of employers.

New documents obtained by STAT's Bob Herman show one of these new methods. Remember how, last year, a wave of Humira biosimilars entered the market and drug companies slashed the list prices of their insulin products? Knowing that rebate dollars from Humira would evaporate as biosimilars catch on, CVS Caremark, a PBM, said it would calculate rebates using a new, complicated explanation and formula that protects its profits. CVS said it would create "rebate credits" — a new term that sounds beneficial but actually penalizes employers that cover lower-cost biosimilars, experts said.

Read more from Bob on how these middlemen are trying to maintain profits wherever they can.


off the charts

Don't underestimate the importance of positive childhood experiences

Most of us know that early exposure to stressors such as poverty, violence, abuse, or racism has long-lasting consequences on our health. But how can parents of young children who experience hardships keep up faith that their child's future isn't doomed from the start?

"Early adversity does not dictate your baby's destiny," writes psychiatrist and STAT columnist Jennifer Adaeze Okwerekwu in her latest piece. She recalls telling one mother that cultivating positive experiences would offer her baby long-term protection. "I also explained that I wouldn't be so passionate about this work if it were devoid of hope," Okwerekwu writes. "She laughed through her tears when I added, 'because all doom and gloom would totally be the worst job ever.'"

Without sufficient understanding of the importance of positive experiences, negative ones may seem to have insurmountable effects, but Okwerekwu assures us that is not the case. "By focusing only on the negative, I fear we are giving parents — and adults who are grappling with their own childhood trauma — the false impression that prevention is the only way to mitigate the health consequences of adverse childhood experiences," she writes. Read more.


research

Smoking disparities between queer and straight people persist, studies say

Tobacco companies love targeted advertising and, for decades, have spent money on promotions directed at LGBTQ populations. And it may have worked, as queer people are consistently reported to smoke more than their straight counterparts. But two new studies go further to show that those who identify as lesbian, gay, and bisexual — especially women — are more receptive to tobacco marketing, more inclined to smoke cigarettes every day, and may even have a harder time quitting.

Researchers from Rutgers Health analyzed survey data on smoking habits, dependence, and receptivity to advertisements. They write that more research is needed on interventions. These studies remind me of some striking survey results that STAT's Nicholas Florko reported on last year: 57% of respondents said they would support a policy to prohibit the sale of all tobacco products.


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What we're reading

  • Kent Campbell, pivotal figure in the fight against malaria, dies at 80, New York Times

  • FDA advisers back CAR-T therapies in blood cancer, despite safety concerns, STAT

  • As more couples struggle with infertility, IVF business is booming, Boston Globe
  • The Boston area built a ton of lab space. Now many of those buildings are opening empty, STAT
  • Transitioning later in life can feel isolating. One social group wants to change that, NPR

Thanks for reading! Until tomorrow — Theresa


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