Breaking News

Negotiating Wegovy's price, bringing genetic therapies to more patients, & the long reach of asbestos

March 21, 2024
Reporter, Morning Rounds Writer
Good morning. Some stories stick with you. "Saving Mila" was one for me, with its depiction of the first girl to have a genetic treatment tailored to her specific mutation. She inspired people far and wide before and after her death in 2021 at 10 years old, Andrew Joseph tells us in his larger story about efforts to find answers for more inherited conditions.

drug pricing

Medicare expected to negotiate obesity drug prices soon, report says

The wave of new obesity drugs has brought with it questions about who will pay for the $1,100 to $1,300 a week the wildly popular drugs cost. By law, Medicare can't cover medications for obesity, but it will pay for seniors to take the same drugs for diabetes and heart problems. A new analysis from the nonpartisan Congressional Budget Office says Medicare will likely choose the obesity drug semaglutide, sold by Novo Nordisk as Wegovy, for price negotiation "within the next few years." 

That choice may be more palatable to Congress than blanket coverage, which could do away with the restriction on obesity coverage. It's not clear how many more Medicare beneficiaries would be eligible for obesity drugs if Medicare were to cover them for obesity, according to the CBO, because many also have  conditions for which the drugs are covered. The FDA recently approved a label expansion for Wegovy's heart benefits. STAT's John Wilkerson has more.


environmental health

The U.S. has banned asbestos, but its effects lingerGettyImages-936802922

Brook Mitchell / Getty Images

The battle may be over, but the war is not yet won. Earlier this week, a new rule from the EPA spelled the end of asbestos in the U.S., but health experts warn that we'll be living with the carcinogen's harmful effects for decades. The new ban covers all forms of asbestos, including the only kind still in use in the U.S., found in brake linings and the manufacture of drain pipe cleaner and chlorine bleach. You may have thought asbestos was already prohibited, but a 1989 ban was all but reversed in 1991, leaving various state regulations in force.

"I think it's a good start, but to see the effects of this [ban] will take a very, very long time," said Emanuela Taioli at Icahn School of Medicine at Mount Sinai. People exposed to asbestos may not develop disease until up to 40 years later. STAT's Annalisa Merelli has more.


health

U.K. researchers and government agencies team up to accelerate individual genetic therapies 

New customized genetic therapies built on now-widespread genetic testing are far from everyday treatments, but they have entered the realm of the possible, raising hopes for children with diseases stemming from the rarest of mutations. To better find answers for more inherited conditions, researchers and government agencies in the U.K. have launched efforts to expand what have been bespoke successes to reach more patients. 

"A lot of the barriers are no longer scientific — we can make these drugs," said Matthew Wood, a professor of pediatrics at the University of Oxford. "It's more about, can we make them at a cost that is reasonable enough? And can we get the regulators to reduce the barriers to doing this so that when a patient shows up, you can actually make a drug quickly enough to benefit that patient, rather than it costing huge amounts of money and taking two or three years to do it?"

STAT's Andrew Joseph reports on two initiatives (Rare Therapies Launch Pad and UPNAT) and tells us how the story of milasen, an N-of-1 drug for a girl named Mila with Batten disease, resonates across the Atlantic.



closer look

Opinion: Add exposure to gun violence to a common screening tool for health careGettyImages-931935708

Saul Loeb / AFP via Getty Images

The adverse childhood experience questionnaire is a crucial tool in medicine, but it could use an update, public health graduate student Sydney Durrah writes in a STAT First Opinion. Gun violence has become so pervasive that the screening tool doctors now use to evaluate their patients' physical and mental well-being falls short: It fails to ask whether someone experienced, witnessed, or was affected by gun violence as a child. Survivors of gun violence face an elevated risk of developing substance use disorders. There has been a surge in antidepressant use among youth and an increase in suicide risk in communities that have experienced school shootings 

"Gun violence represents a distinct form of violence with unique implications for individuals' health and well-being," Durrah writes. "Understanding an individual's exposure to gun violence allows for a precise assessment of community risk factors and resilience." Read more, including what spurred the questionnaire's development in the mid-1990s.


addiction

Drug overdose deaths stayed steady in 2022

After quadrupling over the past two decades, overdose deaths leveled off in 2022, a new CDC report says. The 107,941 deaths were only slightly higher than the 106,699 recorded the year before, a sliver-thin margin that is raising hopes that overdose rates have stopped rising. Most of the deaths involved fentanyl, a potent synthetic opioid that entered the illicit drug supply about 10 years ago. Heroin, methadone, and prescription painkillers have been causing fewer deaths. Other changes: 

  • More deaths now involve such stimulants as cocaine and methamphetamine.
  • Disparities are widening: Overdose rates among white Americans decreased slightly from 2021 to 2022, but overdoses among Black people jumped. American Indian and Alaska Native populations saw the largest increase in overdose death rates, accelerating a preexisting trend in tribal communities across the country. 

STAT's Lev Facher has more.


global health

Falling fertility rates will change populations on a global scale, paper predicts

Taking the very long view, a new analysis of fertility rates around the world predicts a dramatic decline in birth rates and a transformative shift in population patterns by 2100. The Lancet paper estimates that, by 2050, more than three-quarters of countries will see their populations shrink, rising to 97% by century's end. The report also says births will nearly double in low-income regions from 2021 to 2100, when 1 out of every 2 children on the planet will be born in sub-Saharan Africa.

What does this mean? Not too many generations ago, overpopulation was the concern, but now it's a "demographically divided world" that is feared. That's because middle- and high-income countries with a diminishing workforce could strain health and social systems of an aging population. Countries with younger, faster-growing populations might have fewer resources to cope with economic instability, heat stress from climate change, and limited health systems, as well as less access to contraception and education for women. "The global health community must plan to address these divided sets of demographic challenges worldwide," the authors write.


More around STAT
Check out more exclusive coverage with a STAT+ subscription
Read premium in-depth biotech, pharma, policy, and life science coverage and analysis with all of our STAT+ articles.

What we're reading

  • A bat infestation, postponed surgeries, and unpaid bills: a hospital chain in crisis, Wall Street Journal

  • Shadowing Trump's attacks on mental fitness — his own father's dementia, Washington Post
  • Swedish pharmacy bans sale of anti-ageing skincare to children, The Guardian
  • Pharma companies and their allies seek to exempt orphan drugs from state pricing limits, STAT
  • J&J sues former employee for allegedly taking thousands of documents to a new job at Pfizer, STAT

Thanks for reading! More tomorrow,


Enjoying Morning Rounds? Tell us about your experience
Continue reading the latest health & science news with the STAT app
Download on the App Store or get it on Google Play
STAT
STAT, 1 Exchange Place, Boston, MA
©2024, All Rights Reserved.

No comments