Breaking News

Researchers may have found a distinct form of Alzheimer's disease

May 7, 2024
theresa-g-avatar-small - light bg
Morning Rounds Writer and Podcast Producer

At the end of today's issue, you'll find the best sort of news: Casey Ross and Bob Herman are Pulitzer Prize finalists! Read more about their groundbreaking reporting below. And forgive me for a basic plea, but if you find that journalism compelling or important, consider subscribing to STAT+. Right now you can get your first 3 months for just $5. 

 

h5n1 bird flu

Researchers find clues about bird flu transmission by studying cow tissues

MARIO LAPORTA/AFP VIA GETTY IMAGES

A new study looking at the biology of different cow tissues may help to explain the pattern of illness seen in U.S. dairy cattle affected by the H5N1 bird flu outbreak. The study, a preprint that hasn't yet been through peer review by a scientific journal, found that tissue from the mammary gland — in the cow's udder — contains abundant receptors that avian flu viruses like H5N1 can attach to. But cow brain and respiratory tract tissues contained far fewer of this type of receptor. 

That fits with the description of how this virus is behaving in cows, with clear signs of infection in the udders, but little evidence of respiratory tract infections and no reports to date of cows experiencing neurological symptoms. 

Read more from STAT's Helen Branswell on the research and the debate it has sparked about the implications of the cow outbreak for human disease. And in more bird flu news, Helen interviewed WHO chief scientist Jeremy Farrar.


alzheimer's disease

This Alzheimer's gene may cause a distinct form of the disease

Alzheimer's researchers have long considered the gene variant APOE4 to be a major risk factor for most cases of the devastating neurologic disease. But a new study published yesterday argues that it may actually cause a unique form of the disorder. Researchers analyzed data from more than 13,000 people and found that those who carry two copies of APOE4 typically developed dementia and died sooner than people with Alzheimer's who didn't carry the gene variant.

STAT's Jonathan Wosen reports that the findings resemble other specific genetic forms of the disease, like in one well-studied Colombian family. Read more from Jonathan about the new research and what experts thought about it.


cardiovascular health

High blood pressure in kids doubles the risk of cardiovascular disease as adults

Children and adolescents diagnosed with high blood pressure have double the risk of major cardiovascular problems as adults, according to a study published yesterday in JAMA Pediatrics. It's another example of a serious disease striking earlier and earlier, and should encourage routine blood pressure screening, Rahul Chanchlani, the study's senior author, told STAT's Liz Cooney. Read more from Liz on the study and its implications.



first opinion

Measles could come back, but her sister can't

COURTESY EMMI S. HERMAN 

It was February of 1960 when Emmi Herman's sister Marcie — "healthy, precocious" — caught measles from a fourth grade classmate. The viral infection quickly developed into measles encephalitis, a rare form of the disease that can cause permanent brain damage. Marcie made it home from the hospital eventually, Herman recalls, but she was never the same. 

Measles is now a preventable disease, declared "eliminated" in the U.S. at the turn of the century thanks to a vaccine. But in just the first four months of this year, there were more than double the number of measles cases than in all of last year. Why? "Fewer parents are vaccinating their children against measles, their decision most often prompted by social media disinformation," Herman writes. "They should have met my sister," who died in 2020 from Covid complications after living for decades with physical and psychological impairments. Read more in Herman's touching First Opinion essay.


abortion

Pre-Dobbs abortion restrictions tied to more murders of women and girls, study shows

Before Dobbs ushered in a wave of abortion restriction laws, some states limited access by targeting the regulation of abortion providers. In a study published yesterday in Health Affairs, researchers analyzed CDC data on violent deaths and so-called TRAP laws — like mandating physicians have admitting privileges at a local hospital or specifying the width of corridors at a clinic — and found that the laws were associated with higher murder rates for women and girls. 

Between 2014 and 2020, enforcement of each additional law was associated with a 4.4% increase in total murders of women and girls aged 10 to 44, and a 3.4% increase in the rate of those related to intimate partner violence. It's unclear whether the association is driven by the laws or other factors in the states where they were enforced. But overall, the findings complement previous research that has found people denied an abortion were more likely to experience violence from their partner than people who got a wanted abortion.  


addiction

FDA stands by its decision to approve controversial DNA test for opioid addiction risk

Last month, a group of prominent geneticists, public health researchers, and experts in addiction and device regulation urged the FDA to revoke the recent approval of a DNA test called AvertD. Together they argued that the physician-ordered test, intended to help guide doctors' opioid-prescribing decisions by predicting an individual's genetic risk of opioid addiction, lacks a firm scientific foundation. 

In a letter dated May 2, the FDA responded to the group, acknowledging their concerns, STAT's Megan Molteni reports. But the regulator maintained its stance that the test's required "black box" warning, along with a post-market study of the test's performance, should be enough to alleviate their worries. Michael Abrams, of Public Citizen's Health Research Group, told Molteni the letter did not substantively address the group's concerns about the test's validity: "This decision continues to seem like brash, fast-track approval," he said.


kudos corner

STAT's Bob Ross is a Pulitzer Prize finalist for "Denied by AI" investigation

STAT reporters Casey Ross and Bob Herman (a duo who, real ones already know, we affectionately call "Bob Ross" here in the newsroom) were named finalists for the 2024 Pulitzer Prize in the investigative reporting category for their series "Denied by AI," which uncovered how UnitedHealth Group, owner of one of the largest health insurers in the U.S., used an algorithm to deny needed care to seniors. 

When I asked Casey if there's a detail from the stories that stands out to him now, he recalled a phone call between a NaviHealth care coordinator and a woman named Gloria Bent. Bent's husband had just undergone brain surgery to remove a cancerous lesion and was paralyzed on the left side of his body. "Did NaviHealth — UnitedHealth's subsidiary — call to offer support, to help her, to make sure she had the resources she needed? No," Casey wrote to me. "It called at the behest of an algorithm to tell her to get her affairs in order and retrofit her home within two weeks — because that's when payment for her husband's care would be cut off."

You can expect Casey and Bob to stay on the case. "The financial incentive still exists to use AI to deny care," Casey wrote. "Billions and billions of dollars are at stake here, and loosely regulated algorithms will be used to chase after it until lawmakers, or courts, take action to stop them." Read more from their multi-part series.


More around STAT
Check out more exclusive coverage with a STAT+ subscription
Read premium in-depth biotech, pharma, policy, and life science coverage and analysis with all of our STAT+ articles.

What we're reading

  • Federal documents don't provide enough checkboxes for all AAPI ethnicities. That may be about to change, The 19th

  • As livestock move around the country, so does H5N1. The U.S. needs real-time tracking of livestock movements, STAT
  • Are we talking too much about mental health? New York Times
  • The world is relying on the United States to get value-based drug pricing right, STAT

Thanks for reading! More tomorrow,


Enjoying Morning Rounds? Tell us about your experience
Continue reading the latest health & science news with the STAT app
Download on the App Store or get it on Google Play
STAT
STAT, 1 Exchange Place, Boston, MA
©2024, All Rights Reserved.

No comments