health tech
Verily joins in on the GLP-1 gold rush
Google health tech spinout Verily said it's phasing out its chronic disease management app and transitioning to a new, "evolved" product called Lightpath, which will offer GLP-1 drug prescriptions.
Verily has been on a turbulent journey. It started out with moonshot ideas like wristbands that would detect cancer, but searching for a new direction amid turnover among employees and executives, it's now turning to the same idea that many other health tech platforms have already caught on to — prescribing GLP-1s.
Read more from STAT's Brittany Trang.
pharma
Pfizer to partner with Flagship on obesity drugs
Flagship and one of the companies it founded, ProFound Therapeutics, said today they've agreed to identify new obesity treatments in a collaboration with Pfizer.
This is part of a previously announced deal in which Flagship and Pfizer would each invest $50 million to develop 10 drug programs. They said at the time that Pfizer will have an option to acquire each selected program, and Flagship and its companies will be eligible to receive up to $700 million in milestones and royalties for each successfully commercialized program.
The collaboration show Pfizer's renewed efforts to join the booming obesity market after it hit several roadblocks in trying to develop its own medications to rival Novo and Lilly. Last year, it stopped development of a once-daily and twice-daily GLP-1 pill.
drug development
What do Parkinson's and obesity have in common?
Boston-based NodThera is developing a molecule to treat both Parkinson's and obesity, and it's doing so by tamping down on inflammation.
NodThera is studying an NLRP3 inflammasome inhibitor and this morning, it reported that in a Phase 1b/2a study of people with obesity and elevated CRP (a measure of inflammation), the treatment group experienced "highly statistically significant and rapid CRP reduction."
Details of the results are scant, but the company also said that more than 75% of people in the treatment group had a CRP level of less than 2mg/L at 28 days, compared with less than 25% of people in the placebo group.
It's yet to be seen how this treatment actually fares in cutting weight and treating Parkinson's; NodThera is planning Phase 2 studies in those indications. But in the meantime, researchers elsewhere have been looking at the overlap between the two diseases in other contexts.
Early data show that the widely popular class of GLP-1 obesity drugs may also be able to help with Parkinson's. Scientists hypothesize that these treatments may provide benefit by reducing inflammation and protecting neurons from dying.
Earlier this year, researchers in France reported that Parkinson's patients taking an early GLP-1 drug called lixisenatide experienced no worsening of motor symptoms over a year, in contrast to patients on placebo who did.
Novo Nordisk itself has expressed support for the theory that GLP-1 drugs provide benefit by reducing inflammation. Its head of development previously told STAT that follow-up analysis on the landmark Wegovy cardiovascular trial showed that inflammation appears to play an important role in Wegovy's heart benefit.
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