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Fauci will be in the hot seat on Covid today — again

June 3, 2024
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Morning Rounds Writer and Podcast Producer

Happy Monday and happy Pride month! Make sure to catch up on all the news this weekend from the (ongoing) American Society of Clinical Oncology conference. We've got three excellent reporters on the ground there in Chicago.

Also: we are working on our annual summer book list, and we want your contributions!  Submit your favorite reads on health, medicine, and the life sciences here. Relatedly (sort of), is there anyone who reads this newsletter that can get me an advanced copy of the new Sally Rooney? Anyone? Please!!

obesity

Amid criticism, a new study says BMI is still a useful screening tool for youth

Adobe

Your weight in kilograms divided by your height in meters squared. That's all there is to the controversial formula for body mass index, a measurement used as a proxy for body fat. A new study, published today in Pediatrics, found that in children, BMI can detect high levels of body fat as well as a tool that directly measures fat. The study analyzed data from almost 7,000 young people who were screened using both BMI and an expensive, less practical test called dual-energy x-ray absorptiometry.

The research comes over a year after the American Academy of Pediatrics released new guidelines on treating childhood obesity, which also drew pushback from experts concerned about the focus on weight rather than health. The study's authors acknowledged the limitations of BMI, but emphasized that it still could play a role in screening, especially at higher levels of adiposity. Read more from STAT's Liz Cooney on the research.


hormones

Science to watch from a meeting of hormone doctors

ASCO isn't the only conference happening right now — the Endocrine Society annual meeting began this weekend, with researchers presenting a slew of studies here in Boston. It's early days for all of this research, with peer review and publication still ahead, but here's a preview of some that caught my eye:

  • On GLP-1 drugs: The blockbuster obesity medications may have another benefit to add to the roster: Research from the University of Buffalo showed the drugs may lower the risk of recurring acute pancreatitis for people with obesity or type 2 diabetes.
  • On male birth control: NIH researchers presented results from an ongoing clinical trial of a male contraceptive gel that, applied daily, lowered the sperm count for most participants after 15 weeks. The gel includes testosterone, which by itself can decrease sperm production, but a second hormone, segesterone acetate, may speed up the process and keep T at normal levels for the user.
  • On menopause: Experiencing bad hot flashes and night sweats during menopause may be linked to a higher risk of heart and metabolic issues, according to a team of Greek researchers. Of about 100 women in a menopause clinic, those with moderate or severe symptoms had three times the risk for MASLD (née non-alcoholic fatty liver disease), which is associated with cardiovascular disease. 

psychedelics 

MDMA therapy for PTSD will face a crucial FDA panel meeting

It's been more than 20 years since the FDA approved a new treatment for PTSD. And in less than three months, the agency will decide whether or not to add MDMA-assisted psychotherapy to the short list. If approved, MDMA would be the first Schedule I psychedelic — classified by the government as having high potential for abuse and no medical benefit — to be found to actually have a medical use. Tomorrow, the agency will convene a panel of independent scientific advisors to review the evidence.

Ahead of the meeting, STAT's Olivia Goldhill lays out the major issues that will likely come up: There will be questions about blinding and expectancy bias in the research, safety concerns, and how FDA might regulate something that isn't just a drug or a food. The whole conversation will be shaped by the immense need for a new treatment in this space. Read more from Olivia on what to watch out for. 



first opinion

Tired: "Loneliness." Wired: "Social Health"

Adobe

Last year, the U.S. Surgeon General issued a national warning about an epidemic of loneliness. Loneliness comes with serious health consequences, including increased risks of heart disease, dementia, and premature death. The U.S. isn't the first country to recognize this problem: The United Kingdom appointed a minister for loneliness in 2018, and Japan did the same in 2021. But in order to appropriately address the growing, global threat, a policy shift is needed, argues social scientist and writer Kasley Killam.

It's time to update public strategy from reactively responding to loneliness, Killam writes, to proactively promoting social health, the dimension of an individual's overall health and well-being that stems from quality human connections. Researchers have found that people significantly underestimate how important relational factors are for longevity, but a shift in public messaging could turn that around. Read more on her proposals to tackle this public health issue


environmental health

Vermont bans PFAS in menstrual and other products

Last week, Vermont Gov. Phil Scott signed a law banning the use of PFAS (those toxic, infamous "forever chemicals") and other substances in menstrual products. Three states — Minnesota, Maine, and Colorado — have banned PFAS in pads, tampons, and cups, but Vermont is the first to add phthalates, formaldehyde, mercury, and lead to the list. The state's PFAS ban also applies to incontinence products, artificial turf, textiles, cookware, and children's toys.

The move comes about a year after the EPA proposed its first regulations on PFAS in drinking water. No PFAS are good PFAS — while 99% of Americans have the chemicals in our blood, they have been linked to cancer and other diseases, including kidney and liver disease, Crohn's disease, and thyroid cancer, along with other effects like low birth rates and decreased response to vaccines. To stay updated, follow STAT's environmental health reporting


infectious disease

FDA approves Moderna's RSV vaccine

On Friday last week, the FDA approved Moderna's vaccine to protect older adults against respiratory syncytial virus, a.k.a. RSV. It's the company's second licensed product after its Covid-19 vaccine. In a Phase 3 trial of nearly 37,000 people, the vaccine was shown to be 83.7% effective against lower respiratory tract disease caused by the virus. 

The vaccine, for adults 60 and older, arrives a year after two others from GSK and Pfizer were approved for the same age group. (Pfizer's vaccine received a second approval for pregnant people as well.) Read more from STAT's Helen Branswell on why Moderna says this vaccine is different from the rest. 


washington

Fauci in the hot seat on Covid — again

STAT's Sarah Owermohle brings us this report from D.C.: Former top infectious disease official Anthony Fauci will appear before a House committee on the coronavirus pandemic this morning, where besides ongoing questions about shutdown measures and the virus' origins, he's likely to face new grilling about how he and other NIAID staff communicated with each other and the controversy-swarmed EcoHealth Alliance

On Friday, staff Republicans released nearly 500 pages of transcripts from Fauci's January closed-door testimony, teeing up discussions today about masking, vaccine requirements, and gain-of-function research. But another recent testimony from Fauci's former senior advisor David Morens — over, in part, emails referencing "backdoor channels" to avoid federal record trails — is also likely to loom large today. Republicans last week requested more of Fauci's communications records during the early pandemic. Keep an eye out later today for more coverage from our Washington bureau.


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Thanks for reading! More tomorrow,


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