first opinion
Scientists are unsettled by Elon Musk's approach to medical science
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Adobe
Elon Musk has made it clear that his goal for Neuralink, the Tesla CEO's neurotechnology company, isn't strictly to benefit patients. He's also hoping to advance humanity's capability to achieve symbiosis with artificial intelligence. In step with this more unconventional aim, the company takes a different approach to research than most of medical science — and it's rattling the scientific community.
Neuralink keeps details about its ongoing clinical trial tightly guarded, until suddenly broadcasting medical milestones through tweets and YouTube demos. It's only published one peer-reviewed paper, in a journal unrelated to neural engineering. In a new First Opinion essay, medical ethics professor and researcher Anna Wexler explores the pros and cons of Musk's methods, and the importance of disentangling cultural norms from ethical standards. Read more.
clinical trials
Studies of summer: The latest research you also may have missed
Here's another quick rundown from last week. Research on research on research!
- A new surgical technique for below-the-knee amputations could improve walking and help people better control their prosthetics, per a Nature Medicine study. STAT's Timmy Broderick has the story.
- No transgender youth age 12 or younger received gender-affirming surgery in 2019, and any procedures received by minors older than 12 were rare, and mostly chest-related, according to a study in JAMA Network Open. I wrote last summer about a similar study that found even though surgeries tripled between 2016 and 2019, it's an extremely rare intervention for youths.
- Using financial incentives (in addition to standard counseling and drug treatments) can help people who are socioeconomically disadvantaged to quit smoking, according to a randomized clinical trial also published in JAMA Network Open.
- A "visionary" study found long-lasting immune activation in study participants months, and even years, after an initial Covid infection. Researchers even found signs of the virus lingering in people's gut. STAT's Isa Cueto has more.
- Higher inflammation — associated with physical inactivity, chronic illness, and stress — in one's 20s was linked to worse performance on cognitive testing in one's 40s in a research abstract published in Neurology. Great!
obesity
The risks and rewards of GLP-1 weight loss drugs, per two studies
The bad news: There's a potential link between Novo Nordisk's GLP-1 drugs Ozempic and Wegovy and an eye condition that can cause vision loss, according to an observational study published last week. Researchers analyzed data from a cohort of patients with type 2 diabetes and another including patients with obesity. In both groups, the researchers found that NAION cases occurred most frequently in the first year after the medications were prescribed. STAT's Elaine Chen has more on the risk.
But there's some good news too: Separate research published last week found that GLP-1 drugs are more effective in mitigating the risk of 10 obesity-associated cancers than the type 2 diabetes drug alternatives. The retrospective study, published Friday in JAMA Network Open, measured results for a cohort of more than 1.6 million patients with type 2 diabetes from 2005 to 2018 who were prescribed GLP-1s, insulin, or metformin. STAT's Rohan Rajeev has the details on the benefits.
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