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Fruit fly brain map has neuroscientists 'blown away' 

October 3, 2024
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Morning Rounds Writer and Podcast Producer
Good morning! What's something that's blown you away lately? Neuroscientists were recently blown away by the map of a fruit fly brain (see below). I was blown away by how good it feels to successfully build up the walls of a little ceramic cup at a pottery wheel. Then I was equally blown away by how sore my knees were after sitting at the wheel for an hour straight.

infectious disease

No fast answers in Missouri bird flu case

NIAID

If you've been waiting anxiously for answers about whether the person in Missouri who was infected with bird flu passed the virus on to others or not — sorry, we still don't have that information. A CDC official said yesterday that the answer won't be known for at least a couple weeks.

The agency is testing for antibodies in blood samples from several health workers and a household contact of the original case. But first it had to develop a new test, since key genetic changes in the virus mean existing options may not have been reliable, Demetre Daskalakis, director of CDC's National Center on Immunization and Respiratory Disease, told STAT's Helen Branswell. 

The delay will likely fuel concerns about the possibility that there has been human-to-human transmission. Read more from Helen.


we knew them when

STAT icons in big new list of emerging leaders

Yesterday, TIME announced their TIME100 Next, a list that aims to recognize "the diversity of leadership and impact" each year. This year's edition includes some personal favorites of mine, including poet & novelist Kaveh Akbar, Broadway star Cole Escola, and YouTube phenom Amelia Dimoldenberg. And it's déjà vu here at STAT as, once again, we recognize a few of the names on the list:

  • Michelle Morse is a New York City health official and STATUS List 2024 honoree who is working to end racism in clinical algorithms. STAT's Usha Lee McFarling talked to Morse in 2022 about efforts by her and other leaders to confront systemic racism at the Boston-based hospital network Mass General Brigham. 
  • Sholto David is a scientific sleuth who was thrust into the spotlight earlier this year when one of his blog posts on manipulated research images eventually led the Dana-Farber Cancer Institute to retract six papers and correct 31. In January, STAT's Drew Joseph visited Sholto at his home in Pontypridd, Wales. "You can learn all you want about me, but it's not going to change what's true about the papers," he told Drew.
  • Mehreen Datoo's work on malaria — which she was hospitalized for herself while doing research in Uganda — has been critical to the development of a new vaccine that was finally deployed this year. Last month, Drew wrote about the 40-year worldwide quest for a vaccine. 

first opinion

A Louisiana OB/GYN says new law puts her patients at risk

As of Tuesday, Louisiana is the first state to classify misoprostol and mifepristone — known as medical abortion pills — as schedule IV-controlled substances. This puts them in the same category as some narcotics and other medications with potential for addiction and abuse, with federal law requiring them to be stored in locked containers, and, if not used, returned in a very specific fashion. 

In a First Opinion essay, maternal fetal medicine physician Jane Martin argues that the additional tracking and reporting process now required with these medicines puts "an unmeasurable new load on the shoulders of nurses and pharmacists."

"I didn't choose this profession to navigate legal obstacles, but to provide compassionate care during some of the most pivotal and vulnerable moments in someone's life," Martin writes. "Restricting access to medications like misoprostol not only undermines my ability to do so but puts my patients in unnecessary danger." Read more.



science

This fruit fly brain has neuroscientists 'blown away'

Courtesy Flywire Consortium 

How many scientific labs does it take to map the brain of a fruit fly? Almost 50, it turns out. The full map (fancy word "connectome") was published yesterday in a series of papers in Nature. And it's not just about better understanding these little pests: Insights from the map could help researchers better understand how to treat diseases that affect neural circuits, like Alzheimer's and Parkinson's. 

In the past year, researchers have also created maps of a fly larva, a small part of a mouse brain, and one single cubic millimeter of a human brain. "The history of neuroscience can now be divided into two eras, BC and AC," one researcher quipped at a press conference — before and after connectome. To successfully map the whole fruit fly brain expands the boundaries of what neuroscientists are capable of, experts say. Read more from STAT's Anil Oza. 


health tech

Six scientists shaping the field of brain-computer interfaces

It will be several years before a viable brain-computer interface product is on the market, whether it restores movement or sensation or facilitates communication with a computer. But research has dramatically advanced our understanding of what's possible in the nearly 20 years since a neuroscientist first enabled a paralyzed patient to operate a prosthetic arm with just his mind.

STAT's Timmy Broderick has the six people you need to know in the field. Sergey Stavisky, for example, is building a speech decoder to help people communicate after they lose the ability to talk. Mariska Vansteensel chronicled an ALS patient's use of a BCI device at home for seven years in a recent NEJM paper. Read more about the leaders.


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What we're reading

  • A hospital kept a brain-damaged patient on life support to boost statistics. His sister is now suing for malpractice, ProPublica

  • To aid addiction treatment, lawmakers tell DEA to back off buprenorphine enforcement, STAT
  • Breast cancer rates are climbing. Are plastics and cosmetics to blame? Boston Globe
  • ResMed CEO on how wearables, GLP-1s will impact sleep apnea devices, STAT

Thanks for reading! More tomorrow,


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