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A troubling discovery in cows & a promising cancer vaccine study

February 6, 2025
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Morning Rounds Writer and Podcast Producer

Good morning! Yesterday was a big day for the (small? huge?) Venn diagram overlap of STAT readers and One Tree Hill fans because Sophia Bush posted a link to Matt Herper's recent story about vaccines on Instagram. 

Note: I'm only on season 3 of OTH myself, so please don't send spoilers to my inbox.

biotech

The CRISPR companies are not OK

Photo illustration: Christine Kao/STAT; Photos: Adobe

The gene editing tool CRIPSR was supposed to change medicine — just five years ago, a Nobel Prize committee announced that it "may make the dream of curing inherited diseases come true." Billions of dollars were spent chasing that dream, but key scientific hurdles remained unsolved. Now, even when companies achieve encouraging results, that can't seem to stop their stocks from tanking. 

Put simply, STAT's Jason Mast writes, "there are surprisingly few places today where you can both cure a disease with gene editing and make money." For his latest story, Jason interviewed more than 75 investors, academics, executives, analysts, and employees to figure out where, exactly, the vision went off course. 

Read more. (Come for the analysis and stay for the similes. In one section about the hype around CRISPR, Jason describes it "like dropping a 3D printer into a medieval workshop." Later, he says the tool has become "as indispensable to lab scientists as whisks are to pastry chefs.")


hospitals

Some kids with headaches get treated differently in the ED

Black children and Hispanic or Latino children who go to pediatric emergency departments because of a headache receive fewer migraine diagnoses, fewer tests, and less intense treatments than white children who come in with the same symptoms, according to a study published yesterday in Neurology

The study analyzed more than 160,400 visits by children to 49 pediatric EDs between 2016 and 2022. Just 28% of Black and Hispanic children received a migraine diagnosis compared to 46% of white children. Four percent of Black and Hispanic children got an MRI compared to 9% of white ones. And while there was no racial disparity in the number of patients receiving any treatment, Black children were 37% more likely than white ones to receive just oral meds, without any intravenous treatment, and 20% less likely to be admitted to the hospital. Hispanic children were 54% more likely to receive oral meds and 35% less likely to be admitted. 

Further research is needed, the authors write, to understand how these disparities end up affecting kids' health outcomes and to develop interventions to address the inequities.


infectious disease

A troubling discovery in some Nevada cow herds

Four dairy herds in Nevada — previously thought to have the same strain of bird flu that's been circulating in cows all over the country — were actually infected with a different version of the virus, USDA announced yesterday. The version of the virus these cows have is one that has been going around in wild birds that  severely sickened a teenager in Canada last year and led to a death in Louisiana last month. 

The discovery is an important one because it means that driving this virus out of cows will be harder than the agency has estimated, experts told STAT's Helen Branswell. Read more on the new finding and how experts are reacting.



first opinion 

In praise of school nurses

John Locher/AP 

Did you know that in the U.S., there are more security staff in high schools than there are full-time registered nurses? In a new First Opinion essay, RN Sherrie Page Guyer argues that the philosophy of what makes a campus safe must shift "from fear to facts." 

Of course, school shootings are an intractable tragedy in American culture. But Guyer notes that medical emergencies requiring CPR or the administration of lifesaving medication are still far more likely to occur at high schools than a shooting. School nurses can also be the first adult that a student talks to when they need behavioral health support.

Read more in Guyer's essay on the benefits of arming every school with a nurse.  


cardiovascular health

Salt substitutes as a way to lower risk of death, stroke

Scientists have long understood that using salt substitutes — which replace some of the sodium chloride with potassium chloride — can help lower one's blood pressure. A few years ago, for the first time, a randomized controlled trial of more than 20,000 people demonstrated a direct association between use of the substitutes and a lowered risk of stroke. Now, a subgroup analysis from that study, published yesterday in JAMA Cardiology, found that among people who have already had a stroke, using salt substitutes was associated with a significantly reduced risk of having another stroke, and of death.

The subgroup analysis followed more than 15,000 people with a history of stroke for an average of five years. In particular, those in the salt substitute group had a 30% relative reduction of hemorrhagic stroke and 21% relative reduction of stroke-related deaths compared to those who used regular salt. The results show that if scaled up, salt substitutes could be a simple and effective intervention around the world, the authors wrote.


cancer

Some good news re: a cancer vaccine

Nine patients with advanced kidney cancer who received an experimental vaccine tailored to their tumors' specific mutations mounted an immune response to their disease and have remained cancer-free for three years, an early-phase clinical trial has shown. 

Cancer vaccines developed with different molecular recipes are still in their early stages, experts told STAT's Liz Cooney. The study demonstrates the potential of personalized vaccines to change the course of certain cancer types, but larger, longer trials are needed to confirm this approach. Read more on the science.


More around STAT
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What we're reading

  • Foreign aid freeze leaves millions without HIV treatment, New York Times

  • The MAHA era is here. RFK Jr.'s troubles are only beginning, STAT
  • California housing officials recommend state protect renters from extreme heat, KFF Health News
  • Argentina says it will withdraw from the World Health Organization, echoing Trump, STAT

Thanks for reading! More tomorrow,


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