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A viral vaccine study & re-hired FDA employees

February 24, 2025
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Morning Rounds Writer and Podcast Producer

Good morning! I'm writing to you from the laundromat, where a television is blaring sponsored programming about a skin serum made from an "age-defying," "genetically unique" melon. While flashing before-and-after photos of crow's feet, they guess what you may be thinking: "This isn't trick photography!" 

politics

Firings, reinstatements, and hearings

First, let's recap all things health and science that have happened with the federal government in the last few days:

  • The Trump administration has started quietly re-hiring some of the FDA employees that it fired last week in a process that insiders called abrupt and haphazard, STAT's Lizzy Lawrence reports. The total number of employees re-hired is unclear, but at least in some cases, reinstatements appear to be broad. Read more from Lizzy on the specifics.
  • On Friday, a federal judge extended the restraining order on the Trump administration's cap on NIH indirect costs, which had been set to expire today. STAT's Anil Oza was in the court room here in Boston. Read more from him on what's next.
  • More universities have announced that they're reducing or pausing graduate admissions amid the funding cuts. A team of STAT reporters first reported last Wednesday that this was happening. Now, researchers are using a spreadsheet created by microbiologist ‪Carolyn Ibberson‬ to track institutions that are making reductions.

science

A parable on the weaponization of science

You may have seen that a group of researchers released a small, preliminary study last week theorizing that Covid-19 vaccines may be linked in rare cases to a constellation of lingering symptoms not dissimilar to long Covid-like illness.

The paper was posted to medRxiv, a preprint server, midway through Robert F. Kennedy Jr.'s first week at the helm of HHS, when there were already signs that policies promoting vaccines would come under attack. The research exploded online, and as STAT's Helen Branswell writes, became a parable for the ways in which the internet is being used to weaponize basic vaccine research vital to advancing scientific knowledge about the safe use of these key products. Read more from Helen on the dilemmas faced by scientists seeking to advance the field. 


chronic disease

Can treatments for lung conditions go deeper?

Between common chronic conditions like COPD and asthma, and acute harm inflicted by viruses, lung damage is a big problem. Many treatments focus on the upper airways. But to go deeper, researchers are studying the pair found in some Covid vaccines: mRNA + a lipid nanoparticle. 

New research in mice, published Friday in Nature Communications, posits that a similar technology could be used to stimulate healing in parts of the lung not easily reached by conventional therapies. The team reports a nanoparticle, called ionizable amphiphilic Janus dendrimer, targets mRNA therapy directly to the lung and promotes tissue repair.

"If introduced early in the inflammatory process," this mechanism could speed up healing, "ultimately reducing the incidence of complex lung injury and disease," write the authors (several of whom are named on patents and patent applications related to the research).  — Isabella Cueto



politics

'No place is safe' for federal employees with disabilities

BRYAN DOZIER/Middle East Images/AFP via Getty Images 

For many people with disabilities, the way to get a secure job in the federal government is via the half-century-old Schedule A pathway, which helps qualified candidates sail through the otherwise laborious federal hiring process — and helps the federal government meet its mandate of being a "model employer" for people with disabilities. But now, the pathway's mandatory two-year probationary period has left scores of employees with disabilities vulnerable to the Trump administration's stated goal of reducing the federal government's size.

"I was so unlucky for a long time [due to my disability], but I thought [Schedule A] was finally paying off for me. Like God giving back to me," one terminated NIH employee with a physical disability said to STAT's Rose Broderick and Angus Chen. "Now it just makes me feel like no place is safe."

Read more from Rose and Angus about how the cuts have both damaged critical services from the government while also leaving a vulnerable population of disabled workers with fewer options.


aging

The factors influencing when people are diagnosed with dementia

People with lower levels of education, who live alone or in a care home, or who don't have a close relative, are about three years older when they receive an official dementia diagnosis compared to their counterparts, according to a study published Friday in JAMA Network Open that looked at more than 107,000 people in Sweden who were diagnosed with dementia between 2018 and 2022. On top of that, people who had less than a high school education (fewer than nine years) had more comorbidities and took more medications than those with more schooling. 

The results could indicate that these populations tend to have more advanced disease or a poorer prognosis, the authors write. They couldn't say what caused the delayed diagnoses, of course, but hypothesized that the risk of losing a driver's license may play a larger role in when to seek care for people who live alone or have fewer family members. 


commercial determinants of health

Secret shoppers went to NY's unlicensed dispensaries

Unlicensed dispensaries and smoke shops are significantly less likely than licensed retailers to require age verification before somebody enters a store or makes a purchase, according to a secret shopper study published today in Pediatrics. Shoppers went to 37 dispensaries and smoke shops in New York City, also finding that unlicensed stores more often sold products that appeal to young people like energy drinks, soda, and candy. 

Part of the point of legalizing weed is to reduce risk through regulation, the authors write. But in New York, unlicensed retailers outnumber the licensed, regulated ones. In a First Opinion essay last year, three researchers and advocates wrote that, "implementing strong and comprehensive protections for children is not the norm in many states that have legalized recreational marijuana use."

And because we're talking about how easy it can be to get illegal drugs, I must once again remind you of this iconic STAT video


More around STAT
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What we're reading

  • Bad wellness advice is all over social media. These creators are pushing back, NPR

  • Behind the scenes, Mass General Brigham fights Dana-Farber's proposed hospital, Boston Globe
  • Why we don't trust doctors like we used to, Wall Street Journal
  • Is there an amyloid mafia? STAT readers weigh in, STAT

Thanks for reading! More tomorrow,


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