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How Trump's policies will affect intersex health care

March 20, 2025
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Morning Rounds Writer and Podcast Producer

Good morning! There's sure to be a lot of news coming out of the Breakthrough Summit East today, which is taking place just a few blocks away from my favorite Shake Shack in Manhattan. In-person tickets are sold out, but you can still snag a virtual ticket here.

events

On deck at STAT's Breakthrough Summit East

Jason Mast sits on the stage at last year's summit, interviewing two guests. The stage is bright with a red and blue branded backdrop.

STAT

Here's the news you need ahead of the event, and be sure to check in here with Rose tomorrow for a recap. 

  • The backstory on Jim Wilson: Gene therapy pioneer Jim Wilson will speak with STAT's Jonathan Wosen this morning. In 2022, a team of STAT reporters wrote about claims of a toxic, abusive atmosphere at Wilson's Gene Therapy Program. Last year, Wilson made news for leaving Penn and the program, in order to found two new companies. Jonathan spoke to him then about how he plans to commercialize rare-disease drugs at a time when other companies in the space are floundering.
  • Why CRISPR is in crisis: Last month, STAT's Jason Mast wrote a sharp, timely story about how hype, scientific setbacks, and growing investor demands have humbled the gene-editing industry. Re-read the story before tuning in to Jason's conversation today with physician-scientist Kiran Musunuru, who says the field still has potential for the future. (Pictured above: Jason interviewing a parent and a scientist about the challenges of getting CRISPR treatments to patients.)
  • The message from America's favorite science educator: Last fall, STAT's Anil Oza spoke with Bill Nye the Science Guy about a genetic disease that has affected his family for generations. Temporarily re-branded as "the Ataxia Advocate Guy," Nye will join Anil on stage this afternoon to talk more about the history of the disorder and his advocacy work.

addiction

What happens when police and hospitals confiscate drugs?

Between 2020 and 2023, San Francisco police seized opioids from people more than 2,600 times. In that same time, there were more than 1,800 overdose deaths in the city. New research shows that within 100 meters of a given seizure, there was an increased risk of a fatal opioid overdose occurring the very next day. That association — deadly, and statistically significant — persisted for up to a week after the seizure, as well as up to 500 meters away. The farther away — physically and temporally — from a seizure, the less likely an overdose was. 

The authors of the study, published yesterday in JAMA Network Open, write that these seizures, enforcing laws meant to increase public safety, "may be having an unintended negative consequence of increasing risk of overdose mortality." Removing a reliable drug provider can often lead people to find a new, potentially dangerous supply. They go on to say that there isn't any evidence showing that interventions targeting the supply of drugs, actually reduce drug use or related health problems. (What does work? Re-visit The War on Recovery by STAT's Lev Facher.)

Earlier this week, the same journal published another study focused on drug confiscations, this time at hospitals. Researchers analyzing health records and security reports at a Philadelphia hospital found that 79% of room search requests occurred when the patient was there for treatment related to substance use. Forty four percent of those searches turned nothing up, and 23% resulted in the confiscation of illicit drugs or alcohol. Importantly: patients who were subjected to a search request were significantly more likely to have patient-directed discharges, aka leaving against medical advice. 



first opinion

New policies could worsen intersex health care 

a "moody" stethoscope lays facedown on a black surface, in shadow

Adobe 

Kimberly Zieselman was born intersex. You may not have heard of intersex traits — variations in someone's sex anatomy that don't align with binary categories of female or male — but they're as common as red hair, green eyes, and more common than identical twins. "We have always been here," Zieselman writes in a new First Opinion essay.

For decades, people with intersex traits have been subjected to medically unnecessary and often nonconsensual surgeries, so they might better fit inside the category of male or female. Zieselman writes that she's never been able to find competent intersex-affirming health care. And she fears that the Trump administration's policies around sex and gender will make health care even worse for people like her. Read more about her personal experience and how new policies might affect her. 


chronic disease

ME/CFS research program at Columbia is shut down

At Columbia University, the Center for Solutions for ME/CFS is one of few places in the country fully devoted to studying the condition known as chronic fatigue syndrome. Now, the large research program has been forced to shut down because of the Trump administration's cuts to the university's funding, one of its top researchers told STAT's Isabella Cueto. 

Columbia is allowing the center to keep paying salaries for workers who were supported by the slashed grants, but they can't purchase supplies to continue research or fill any newly vacant positions.Three projects at multiple institutions involving thousands of patients hang in the balance: a large genetics study, another one searching for infections that can lead to ME/CFS, and a third to analyze patients' self-reported symptoms in an app and compare them with biological markers. 

It seems to be the second time that the administration's cuts at Columbia have struck programs focused on chronic disease, despite emphasis from Trump and other officials that it's a major priority. Read more from Isa on the latest.


nutrition

California makes moves on ultra-processed foods at school

California lawmakers are seeking to remove ultra-processed foods deemed "particularly harmful" to both physical and mental health from the state's school lunches by 2032. The bill proposes the first legal definition of ultra-processed foods in the country, while scientists have yet to come to a consensus on the definition. Broadly, it's understood to refer to foods that are industrially produced and contain additives like artificial flavors, emulsifiers, preservatives, and synthetic dyes.

The move is indicative of how states are stepping into a perceived vacuum left by the federal government, STAT's Sarah Todd reports. Read more on how much support the bill has, and what it would mean if it passed. 


More around STAT
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What we're reading

  • Trump administration extends opioid emergency as fentanyl deaths drop, NPR

  • HHS agency responsible for health care quality research threatened with mass layoffs, STAT 
  • How do I convince my husband to get tested for ADHD? The Cut
  • FDA warns Aspen Pharmacare, Africa's biggest drugmaker, over sterility issues at a key plant, STAT

Thanks for reading! More tomorrow,


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