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Why women are more likely to get Alzheimer’s

March 6, 2025
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Morning Rounds Writer and Podcast Producer
Good morning! We're running from one confirmation hearing to another this week at STAT. Check out the recap below of yesterday's hearing for Jay Bhattacharya, the nominee to lead NIH. And you can follow STAT's live blog today for the hearing with Marty Makary, who is in line to lead the FDA. 

politics

What you need to know from the confirmation hearing for NIH director

JIM WATSON/AFP via Getty Images

Jay Bhattacharya is "convinced" that vaccines don't cause autism — but in his confirmation hearing in front of a Senate committee yesterday, he wouldn't rule out funding even more research to provide vaccine skeptics with "good data." He doesn't believe that ideology should determine the direction of science, yet he wouldn't commit to restoring NIH research funding for LGBTQ+ issues. He often called for addressing public distrust in science rather than directly answer questions that might put him at odds with President Trump or health secretary Robert F. Kennedy Jr.

The theatrics that played out yesterday aren't likely to have an effect on the vote. As STAT's Eric Boodman writes, Bhattacharya is considered a shoo-in. But the nominee's responses to each question provide a glimpse of how he may lead the agency.

Read more in Eric's sharp analysis of the hearing. And if you missed it, go back to his profile of Bhattacharya from earlier this week to learn more about the many contradictions of this wonky-economist-turned-Covid-firebrand.


infectious disease

The latest on Ebola in Uganda

Investigators are still trying to figure out how Uganda's most recent Ebola Sudan patient, a 4-year-old boy who died last month, because infected. The case, which was only diagnosed after his death on Feb. 24, was a sign that an outbreak the country thought had been controlled was perhaps still ongoing.

A report from WHO's African regional office, posted online Wednesday, revealed that the boy's mother had given birth in a health facility in Kampala on Jan. 23. She died following an acute illness on Feb. 6 and her newborn died six days later. Neither was tested for Ebola but both are now considered probable cases. The first known case in this outbreak, a male nurse who worked in a Kampala hospital, developed a fever on Jan. 19 and died on Jan. 29. Investigators are trying to determine if the nurse could have infected the woman, if the two had a common exposure to the virus, or if the woman was infected another way. A total of 201 new contacts are being monitored. To date there have been 10 confirmed and two probable cases.It appears that the information about the two probable cases was removed from the report after it was first published. The original can be viewed online here. — Helen Branswell


research

Why women are more likely to get Alzheimer's

At a time when including the word "women" in research grants has triggered special review at the NIH, the journal Science has published an entire special issue devoted to new research and perspectives on women's health. The collection, out yesterday, highlights studies on the interplay between hormones, chromosomes, and dementia, and includes essays arguing for the importance of studying sex differences throughout biomedical research.

"The menopause transition specifically might be an important key to help us unlock the biology of Alzheimer's disease, and this is knowledge that will promote health for all brains," Madeline Wood Alexander, one of the study authors, said to STAT's Liz Cooney. Read more from Liz on the findings and what research is still needed.  



first opinion

While incarcerated, he served as a CNA during Covid. Here's what he saw

David Goldman/AP

In Connecticut state prisons, the work of caring for sick, injured, or dying people often falls to certified nursing assistants who are incarcerated themselves. Abraham Santiago trained while incarcerated in a maximum security prison to become a CNA, just in time for the pandemic to hit. He then spent two years taking care of people in a special medical isolation unit. 

By the spring of 2023, 30 men from the state's prisons had died with Covid, many of them holding Santiago's hand. Working 24 hours a day in two-week stints, Santiago monitored patients; fed, clothed, and bathed them; helped them do physical therapy exercises; cleaned their wounds. "For this work, we earned $1.75 a day," he writes in a new First Opinion essay.

"Being a CNA utterly transformed my life and, most importantly, my soul," he continues. Read more in Santiago's intimate essay about the people he met during that time, and how they changed him.


public health

A state-by-state breakdown of LGBTQ+ youth mental health

Yesterday, the Trevor Project released new state-by-state analysis of its annual national survey of queer young people. The survey, administered to more than 18,000 people ages 13 to 24 last year, is one of few large datasets on LGBTQ+ people and their mental health — it asks the same questions about suicide as the CDC's Youth Risk Behavior Survey, so that the results can be compared to the general population of young people. There's already a dearth of health data on trans people especially. And now that the CDC has said it will stop processing trans identity data, including on the YRBS, research like this from the Trevor Project may become even more critical.

The data for last year's report was collected between September and December 2023. Here are some interesting findings from the latest analysis:

  • LGBTQ+ young people living in southern states had some of the highest rates of wanting, but being unable to access, mental health care. (This was the case for 63% of respondents in South Carolina and 60% in Texas, compared to 50% in California and 44% in New York.) 
  • Those in Southern states also suffered from some of the highest rates of discrimination based on their sexual orientation or gender identity. (In Arkansas, 66% of respondents, but 54% in Massachusetts.)
  • LGBTQ+ young people living in the Midwest reported some of the highest rates of suicidal thoughts and attempts. (In Ohio, 43% of respondents reported suicidal thoughts and 12% reported attempts. In Rhode Island, it was 37% and 8% respectively.)

health tech

How Trump's early actions imperil efforts to improve AI in medicine

In his confirmation hearings, health secretary Robert F. Kennedy Jr. called on technology to solve America's rural health care crisis. For years, there's been a massive push to adopt AI across the American health care system, especially in underserved areas. But as STAT's Katie Palmer reports, that vision is far from reality. And now, critical work to improve that technology and narrow performance gaps is being delayed and stifled in response to President Trump's early executive actions.

"You cannot do AI without a focus on equity and disparities and fairness," said Leo Celi, who directs research at an MIT lab. Researchers, health systems, and regulators are struggling to interpret the impact of executive orders, communications freezes, and staff reductions across federal health agencies. As researchers prepare for deeper cuts, the uncertainty is already having a chilling effect on clinical AI research. Read more from Katie.


More around STAT
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What we're reading

  • Florida seeks drug prescription data with names of patients and doctors, New York Times

  • What ketamine does to the human brain, The Atlantic
  • Years later, Centene settlements with states still unfinished, KFF Health News
  • CDC invites back about 180 fired employees, including some who help fight outbreaks, AP

Thanks for reading! More tomorrow,


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