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The 'blueprint' to NIH — published where?

April 3, 2025
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Morning Rounds Writer and Podcast Producer
Good morning and happy Thursday. The big news week continues, so read on:

politics

The latest on this week's big federal health cuts

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Kayla Bartkowski/Getty Images

STAT reporters have continued to get a clearer picture of how the cuts to federal health agencies are playing out, and the specific groups getting hit the hardest:

More than half of employees at the Office of the Assistant Secretary for Planning and Evaluation and the Agency for Healthcare Research and Quality have been laid off, STAT's Bob Herman and Tara Bannow report. The two agencies made up about 0.04% of the federal government's health care spending, but experts worry that gutting the departments will undercut efforts to improve care delivery and introduce political interference into data-driven organizations. Read more.

The majority of staff, including the entire management and regulation divisions, were cut from the FDA's Center for Tobacco Products, STAT's Sarah Todd reports. The center has drawn criticism from all sides in recent years, and former officials, researchers, politicians, and others told Sarah that the cuts will only exacerbate problems with tobacco regulation and enforcement in the U.S. Read more.

At the NIH, scientists and other staff are left wondering where the agency is headed amid the cuts. Yesterday afternoon, a group of scientists sued the agency, arguing that an "ideological purge" of research funding is illegal and threatens medical cures. But a paper published last week — titled "A Blueprint for NIH Reform" — is circulating in academic circles, and may provide a clue to what agency leadership has in mind. It was written by Martin Kulldorff, a collaborator of the agency's new director, Jay Bhattacharya, who is also on the editorial board of the publication, called the Journal of the Academy of Public Health. STAT's Anil Oza wrote about the details of the blueprint and what scientists think about it. Read more.


science

How the shingles vaccine protects against dementia

As vaccines become more political than ever, a new study shows another benefit: getting the shingles vaccine could protect against dementia. The paper, published yesterday in Nature, found that people who received the vaccine had a 20% lower risk of later developing dementia than those who didn't. The shot had no other impact on other common health problems for older adults like heart disease, lung infections, or cancer.

The researchers came to this finding through a natural experiment. They looked at 300,000 electronic health records collected randomly from people born between 1925 and 1942, comparing those with birthdays on either side of one fateful day in 1933 that made people eligible for the shot when it was introduced in 2006.

"I was scared to put this up because it's such a different approach from what's generally done in epidemiology and medicine," Pascal Geldsetzer told STAT's Megan Molteni last fall, when she first wrote about the research as a preprint. "We're looking at a causal effect. … There is something clearly going on here." Read more



policy

Meanwhile, at the Supreme Court

Three health-related cases came before the high court yesterday. Here's what you need to know:

The justices ruled unanimously in favor of the FDA in a case regarding the agency's crackdown on sweet-flavored vapes. It did not violate federal law, they said, by denying a company's application to sell flavors like "Jimmy The Juice Man in Peachy Strawberry" and "Suicide Bunny Mother's Milk and Cookies." But the battle isn't quite over yet — read more

The court also ruled in favor of a truck driver who failed a drug test and lost his job after taking a CBD supplement for chronic pain that was advertised as not having THC in it. In a 5-4 decision, the justices decided that Douglas Horn can continue with an anti-racketeering lawsuit to hold the company that made the product responsible. 

Later in the morning, the court heard oral arguments in Medina v. Planned Parenthood South Atlantic. In 2018, the governor of South Carolina issued an executive order prohibiting any clinic where abortions are performed from participating in state Medicaid. The Supreme Court is considering one specific question: Can people on Medicaid sue the state over a ban like this, citing the Medicaid Act's free choice of provider? Planned Parenthood argued that patients should be able to do so, while the Trump administration and South Carolina said no. 

The justices are expected to issue a ruling by the end of the term this June. The outcome will have implications for people seeking reproductive care in South Carolina, but also in several other states that have similarly attempted to keep Planned Parenthood out of their Medicaid networks. If you want to learn more, KFF published a great primer on the case, and Vox's Ian Millhiser wrote some helpful analysis after the arguments about how politics could interfere with the law.  


first opinion

The pharma scandal you forgot

Erythropoietin — also known as EPO — is mostly remembered as one of the drugs that cyclist Lance Armstrong used to win seven Tours de France wins. But what you may have forgotten, or never known, is the role this blood thickener played in a disaster that by one estimate cost nearly half a million people their lives.

It started in 2003, when a study concluded that EPO could be killing cancer patients. Johnson & Johnson sold it as a cancer treatment under the brand name of Procrit, and experts initially assumed the study was an outlier. But it wasn't the first study to come up with these alarming results — months earlier, a study found that almost three times as many participants died when taking Procrit as did in the placebo group. So what happened? 

"Lies, feckless government oversight, and the participation of nearly every oncologist and cancer hospital in the country are all part of this story," writes Gardiner Harris in a new First Opinion essay. Read more.


More around STAT
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What we're reading

  • Miscarriage and motherhood, Atlantic

  • New York City's health department just lost $100 million in federal funds. That has consequences, STAT
  • The Cory Booker endurance test, New York Times
  • Decimation of HHS comms, FOIA offices will leave Americans in the dark about urgent health matters, STAT

Thanks for reading! More tomorrow,


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