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A battle of priorities in the war on chronic disease

May 20, 2025
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Morning Rounds Writer and Podcast Producer
Good morning, happy Tuesday. My colleagues Isabella Cueto and J. Emory Parker have a great, meaty MAHA policy story for you today. Scroll down to read more, or just dive in.

first opinion

The expert on presidential health weighs in

Joe Biden looks to the left. There's a deep blue hue around his face.

ROBERTO SCHMIDT/AFP via Getty Images

Lawrence Altman, a physician, professor, and former journalist, has reported on the health of every American president since Ronald Reagan. Last year, when President Joe Biden was still adamantly running for re-election, Altman wrote for First Opinion about an increasingly relevant question: How old is too old to be president of the United States? Yesterday, he pointed out in a new essay that much of the Monday-morning quarterbacking around former President Biden's cancer diagnosis — and why it wasn't detected earlier — is contrary to best-practice medical guidelines.

"The diagnosis underscores the fact that cancers can sometimes pop up suddenly, even among recipients of the most sophisticated care doctors can offer," Altman wrote. Read more.


innovations

The first human bladder transplant

Two weeks ago, surgeons from Keck Medicine of USC and UCLA Health performed the world's first-in-human bladder transplant as part of a clinical trial. Currently, if someone's bladder stops working or needs to be removed, they'll get a surgery that involves using a portion of their intestine to create either a neobladder, or a route for urine to drain into a bag attached to the outside of their body. 

The 41-year-old patient received both a kidney and a bladder from the donor, after having been dependent on dialysis for seven years following the loss of the majority of his bladder and both kidneys to cancer. In a press release, the surgeons note that the patient's new kidney immediately made a lot of urine and there was no need for dialysis. He was discharged after about a week, and was able to urinate with the new bladder, a USC media relations manager told STAT. But it will be most important to see how he recovers with the organs long-term.


policy

NIH director lays out agency priorities during contentious town hall

NIH Director Jay Bhattacharya on Monday laid out a five-point agenda for the agency, with areas of emphasis including chronic disease, academic freedom, research reproducibility, funding innovative science, and transparency. But not everyone made it to the end of his remarks, according to a recording of the event reviewed by STAT. When Bhattacharya, a former Stanford health economist and critic of Covid-era lockdowns, said that he now believes that NIH-sponsored research caused the pandemic, dozens of agency staffers walked out of the town hall, eliciting applause.

"I'm actually pleased to see the walkout, because I very firmly believe in free speech," Bhattacharya said. The agency director stressed that he's doing everything he can to restore normal agency functions. When a staffer told him they could not order gloves, Bhattacharya assured them his staff would fix the issue. Addressing low morale at the agency after mass layoffs in recent months, he said, "It's been a very difficult time, and, of course, you have ideas that may differ from mine. It's only by talking to each other that we're going to move forward." — Jonathan Wosen



chronic disease

The ongoing battle over MAHA priorities

A graph of the top chronic diseases in the U.S. Hypertension tops the list, followed by obesity, high cholesterol, arthritis, depression, diabetes, asthma, chronic obstructive pulmonary disease, stroke, dementia, and chronic kidney disease. (In that order!)
Robert F. Kennedy Jr. has a deadline coming up. His MAHA Commission must deliver a diagnosis of the nation's epidemic of chronic disease to the White House by the end of the week. By the end of summer, it will need to offer solutions.

The stakes are high. Chronic diseases topped infectious illnesses as the leading driver of death over a century ago. But even as Americans live longer, many are spending those extra years living with chronic conditions — watching their health and quality of life deteriorate. So what's most important: taking on the leading killers like heart disease and cancer? Investigating the connection between infectious disease and chronic conditions? Cutting federal spending?

STAT's Isabella Cueto and J. Emory Parker have created an in-depth and interactive (!!!) guide to the baseline of the problem and how the commission might choose its prime concerns. Spend some time with the story.


addiction

Most youth overdose deaths driven by fentanyl alone

For years, synthetic opioids like fentanyl have driven an increase in fatal overdoses among young people in the U.S., despite the fact that youth drug use hasn't generally increased. A new study, published today in Pediatrics, examined what combinations of drugs were most common when a young person (in the study, ages 15 to 24) died from an overdose between 2018 and 2022. To the researchers' surprise, they found that deaths involving synthetic opioids alone, as opposed to in combination with other drugs like cocaine or prescription opioids, rose by 168% over those years. Synthetic opioids taken alone also had the highest rate of fatalities overall, which was true regardless of race, ethnicity, or sex.

The study authors pointed to an increased availability of counterfeit pills that contain exclusively synthetic opioids as one potential driver of this trend. They noted that youth are likely to use pills that they believe are prescription drugs, but could actually be completely synthetic. They also pointed out that harm reduction services can often have age restrictions, making it harder for young people to engage.


budgets

"The currency of the realm is fear" 

On late Sunday night, Republicans on the House Budget Committee passed a reconciliation bill with more than $700 billion in federal funding cuts to Medicaid. The bill has one more stop, at the House Rules Committee, before it goes to the House floor for a vote. 

Although moderate and conservative Republicans disagree over some Medicaid policies that have been considered, both factions support imposing work requirements on adults without kids or disabilities. That means the bill leans hard on that policy, applying work requirements for people up to age 64 instead of 55. Those requirements would take effect in 2029, though conservatives are demanding they start next year. Asked on Thursday if that start date was chosen to avoid angering voters before the next presidential election, Rep. Byron Donalds (R-Fla.) responded, "Man, the currency of the realm is fear." Read more.


More around STAT
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What we're reading

  • For the first time, the U.S. is absent from WHO's annual assembly. What's the impact? NPR

  • Why sunblock in the U.S. is so much worse than in the E.U., STAT
  • The U.S. hasn't seen a human bird flu case in 3 months. Experts are wondering why, AP
  • Postdoc fellowship paused by Howard Hughes Medical Institute, STAT

Thanks for reading! More tomorrow,


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