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How one elite rehab center is using GLP-1s for addiction

July 14, 2025
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addiction

How one elite rehab center is 'obliterating' all kinds of cravings with GLP-1s

A binder with GLP-1 information in Steven Klein's office at Caron Treatment Centers in Wernersville, Pa.

Rachel Wisniewski for STAT

Ever since blockbuster weight loss medications burst on to the scene, GLP-1s have shown promise as not just a way to lose weight, but to revolutionize our understanding of desire. Early data showing the potential to treat addiction has been particularly exciting. But only a handful of clinical trials are underway, with several unlikely to publish results within the next two years.

That doesn't matter to three doctors at an elite nonprofit rehab facility, all of whom are in long-term addiction recovery themselves. In recent months, these clinicians have begun prescribing semaglutide to patients to help treat the addictions that brought them there. "I don't think of this as doing anything Wild West," said Steven Klein, one of the doctors involved. "We're using something off-label under the umbrella of addiction, whether that be food, sex, alcohol, or opioids."

Read the story from STAT's Lev Facher about the protocol these doctors are using for their new, off-label initiative, and how their own journeys with addiction, and a fateful introduction from one Alcoholics Anonymous sponsor, brought them together.


since u been gone

The biggest news from last week

Were you lost without the newsletter last week? Here's a recap of the biggest news you might have missed:

  • The U.S. has seen more confirmed cases of measles this year than any other in more than a quarter-century, STAT's Helen Branswell reported. And of course, we're only halfway through the year. Read the story and watch the video on what it means.
  • Morale is low at the FDA, as the steady erosion of staff slowly compromises the agency's work, STAT's Lizzy Lawrence reported. "There's no sense of stability, and every time you've turned around someone is leaving," one employee told Lizzy. Read the story that the Economist's health editor Natasha Loder called "a damning report on the reckless destruction at the FDA."
  • Starting today, the Trump administration will further curtail undocumented immigrants' access to federally funded programs, including health care clinics, early childhood education, and nutritional support. The decision reverses a federal practice that has been in place for decades, and is likely to cause widespread fear among immigrant communities, STAT's Isabella Cueto reported. Get the details.
  • The DOJ has issued "nearly 20 subpoenas" to clinics that provide gender-affirming care to young people, on top of an unknown number to drug manufacturers who make the medications used for this treatment, its chief of staff said last week at an FTC event. (Later, the DOJ announced it sent more than 20 subpoenas to clinics and physicians.) I wrote about how both the DOJ and FTC are joining President Trump's attack on trans health care. Read more.
  • MAHA's European food envy is full of contradictions, as STAT's Sarah Todd reported. Kennedy and other leaders in the MAHA movement talk a lot about how much better European food is, drawing a connection between its policies on additives and the region's lower rates of chronic disease. But nutrition experts told Sarah that MAHA is also overlapping some key differences across the pond that have a much larger impact on health. It's a really interesting story — read it. 


one big number

763%

That's how much reports of young children accidentally eating nicotine pouches rose between 2020 and 2023, according to a study published today in Pediatrics. Usually, the children were fine, apart from some nausea or vomiting. But there can be severe consequences: 1.2% had serious medical outcomes like seizures or respiratory failure, and two children, both under age 2, died after consuming liquid nicotine. STAT's Sarah Todd has the details.


public health

The links between different gun laws and types of gun deaths

Research has shown that, for the most part, stricter gun laws are correlated with fewer gun deaths. A new study, published in JAMA Network Open, aimed to analyze what types of legislation are most effective at preventing suicide versus homicide by firearm. The researchers found that laws that regulate sales, transfers, and permitting for guns are most strongly correlated with a reduction in suicides. When it came to homicides, sociodemographic factors like unemployment and poverty played a bigger role than legislation. To get there, researchers analyzed firearm deaths and gun laws between 2017 and 2022 using data from the CDC and Giffords Law Center

"These results are not just statistically significant, they are politically and morally clarifying," wrote physician Joseph Sakran in an accompanying editorial. He urged clinicians, policymakers, and communities to resist one-size-fits-all solutions and to pursue both gun regulations and policies to address the sociodemographic struggles that also play a role.


mental health

Does court-ordered treatment for serious mental illness actually work?

In the last decade, the federal government has provided $146 million to organizations that provide outpatient care to people with serious mental health conditions like psychosis. The people were ordered to undergo treatment so they wouldn't be a threat to themselves or society.

But whether or not you think this sort of involuntary treatment works might depend on who you ask. HHS has looked at its effectiveness over the years, generally finding favorable outcomes. Now, a new Government Accountability Office report is suggesting those earlier conclusions are not reliable because of methodological flaws in how the assessments were made. STAT's O. Rose Broderick walks through the evidence in her latest.


More around STAT
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What we're reading

  • Texas overhauls anti-abortion program that spent tens of millions of taxpayer dollars with little oversight, ProPublica

  • The growing influence of vaccine skeptics inside HHS, STAT
  • Who's policing opioid settlement spending? A crowdsourced database might help, KFF Health News
  • 25 years ago, I reported on horrifying hospital errors. Here's what's changed since then — and what hasn't, STAT

Thanks for reading! More next time,


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