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An autism overhaul, a new Apple Watch feature, & a gene drive project shut down

September 23, 2025
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Morning Rounds Writer and Reporter
Good morning. Yesterday's newsletter included the wrong link to an investigation by STAT's Tara Bannow into how some hospital leaders are discouraging infection testing. This link will take you right there. I hope you'll read the story, if you haven't already.

politics

At autism event, Trump veers into anti-vax rhetoric

A close-up of President Trump speaking at the White House

Andrew Harnik/Getty Images

President Trump outlined a dramatic overhaul to federal health agencies' approach to autism at a White House event yesterday afternoon. First: His administration has concluded that some cases of autism may be linked to pregnant women's use of acetaminophen (the active ingredient in Tylenol) and that the medication should be used sparingly and only if absolutely needed during pregnancy. STAT's O. Rose Broderick has the details on the full announcement. (The event took a turn when Trump started proposing major upheavals to childhood vaccination based on his personal feelings about the issue. STAT's Daniel Payne, Anil Oza, and Chelsea Cirruzzo have more on that.)

In tandem: the FDA has reapproved as an autism therapy a drug that stopped being sold more than 25 years ago. The drug, GSK's Wellcovorin, is a branded version of leucovorin, a widely available generic drug generally used to help tame the side effects of drugs. STAT's Andrew Joseph writes with Daniel on what HHS is calling the first FDA-recognized treatment pathway for autism.

If you're looking for a clear breakdown of the evidence around Tylenol as a potential cause of autism and leucovorin as a potential treatment — Matt Herper has you covered. The questions of whether acetaminophen can cause autism, or leucovorin can treat it, have already been studied to a fair degree, he writes. Read more on correlation vs causation and the strength of the research. (And there's this previous banger from Matt, too: How we know that vaccines don't cause autism.)


hospitals

ED deaths increase after private equity comes in, study says

After hospitals are acquired by private equity firms, patient deaths in the emergency room go up by about 13%, according to a study published yesterday in the Annals of Internal Medicine. At the same time, full-time staff and salary expenditures are cut by nearly 12% and 17% respectively. There aren't more patient deaths in the ICU, but those patients do see more transfers and slightly shorter stays. To understand these changes, the study authors analyzed data from 49 private-equity-owned hospitals and 293 matched controls. (Those percent increases are all relative to the control group.)

The results track with earlier research by the same team that found complications spiked 25% in hospitals bought by private equity. And for people with intellectual or developmental disabilities, rising PE ownership of care facilities has led to abuse, neglect, and even deaths.

The authors conclude that in hospitals, the reductions in salary expenditures "could be a key mechanism by which cost cutting after private equity acquisition contributes to changes in clinical care and patient outcomes." (Despite the cost-cutting, existing evidence shows that private equity buyouts actually drive up health care costs.)


health tech

Can this new Apple Watch feature actually help?

Over the last decade, Apple has gradually expanded the features on its popular watch that alert users of dangerous health conditions. The latest notifies users that they may have hypertension, or high blood pressure, which afflicts about half of all American adults, though many don't know it. 

One thing to know: In a clinical trial of 2,200 people without a diagnosis, this new feature caught less than half of all hypertension cases. But as STAT's Mario Aguilar explains, screening algorithms like these walk the line between correctly identifying enough people who have a condition and minimizing false positives. Read more from Mario on how the new feature works, how well it works, and what experts think about it. 



games

8 Across: NIH branch concerned with OTC vitamins?
The words "STAT MINI" stand next to a phone with a blank, colorful crossword grid.

Julia Bujalski/STAT 

Guys, I have to admit — I find the STAT mini crossword puzzle pretty challenging!!! I was stumped by the above clue. But I did get the combination of 1 down and 4 across. Did you? Try this week's puzzle.


global health

A gene drive project shut down in West Africa

An ambitious gene drive project in West Africa's Burkina Faso has been shut down by the country's government, according to reporting from Science earlier this month. Scientists from the international nonprofit Target Malaria described a "brutal, humiliating" raid by judicial police in which offices and laboratories were sealed off like a crime scene and scientists were checked for mosquitos in their pockets. 

Since 2012, the group had been working to develop genetically modified mosquitoes to help fight malaria across the continent. Former STAT reporter Ike Swetlitz wrote about the work in 2017. At the time, no living organism with a gene drive had ever been set free. In 2019, researchers from Target Malaria released their first round of genetically modified mosquitos. The project used to have government support, but according to reporting in Science, local opposition has grown in the last year, in part due to false accusations online about the group weaponizing mosquitos to spread disease or sterilize people. I recommend revisiting Ike's first story, which includes details of how the project's scientists were building trust within communities. 


policy

After cutting SNAP benefits, Trump admin cancels federal food insecurity survey 

The Trump administration's cuts to the food benefits program SNAP have critics worried that more people are going hungry. Now the Department of Agriculture is also canceling the annual food insecurity survey that tracks how many Americans are struggling to put enough food on the table, calling the 30-year program "redundant, costly, politicized and extraneous."

Research shows food insecurity is linked with a number of chronic diseases, including heart disease and diabetes. The timing of the survey's cancellation means that the government won't have a way to assess the impact of eliminating food benefits for an estimated 2.4 million Americans, or of other policies.

The most recent data, from 2023, shows that food insecurity is rising, affecting 13.8% of people in the U.S. compared to 12.8% the previous year. The food insecurity survey has been lauded for using language that helps researchers identify experiences of deprivation even when people might not self-identify as hungry — for example, asking whether they'd skipped meals or eaten fewer foods because of money concerns. — Sarah Todd


first opinion

Raise your hand if you have ever been personally victimized by the wellness industry

Ana Ivkovic Smith is psychiatrist, a mother, and "an increasingly anxious wellness enthusiast," as she puts it. In a new First Opinion essay, she explains how some of the worst anxiety she's dealt with hasn't come from those first two identifiers, but from the third. 

It started out as an innocent, evidence-based interest in functional medicine. But things quickly became overwhelming. "I installed three different water filters in my house," she writes. "I avoided certain fruits after reading about their impact on blood sugar. I grew fearful of lectins, oxalates, and phytates — compounds found in otherwise healthy plant foods like beans, nuts, and seeds that allegedly interfered with nutrient absorption. … This wasn't health — it was obsession." Read more about her journey and how the nocebo effect could be at play with wellness industry scare tactics. 


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What we're reading

  • CDC says it's coordinating with the WHO, White House on Congo's Ebola outbreak, NOTUS

  • First Opinion: Refugees need — and deserve — dental care, STAT
  • If AI can diagnose patients, what are doctors for? New Yorker
  • The Heritage Foundation wants transgender people and allies designated as terrorists, Advocate

Thanks for reading! More next time,


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