research
Cannabis drug works for chronic lower back pain, per study
A cannabis extract containing 5% THC called VER-01 is safe and effective to improve chronic lower back pain without risk of dependence or withdrawal symptoms, according to a phase three randomized controlled trial published yesterday in Nature Medicine. The study included 820 adults, about half of whom took the drug while the other half took a placebo. On a 10-point pain scale, patients who took the drug saw a nearly 2-point reduction in pain levels after three months of treatment, as compared to a 0.6 point reduction for the placebo patients.
Patients who took the drug did not show signs of abuse or dependence. Still, about 83% experienced some sort of adverse event as opposed to 67% of the placebo group. Dizziness, fatigue, nausea, dry mouth, and drowsiness were most common for the cannabis group, and 17% of participants in that group ultimately discontinued the study due to those symptoms, as opposed to 3.5% in the placebo group.
Still, the authors found the pain reduction meaningful, and believe that the cannabis extract could become a key alternative to NSAIDs and opioids. Another trial directly comparing the drug to opioids has already been completed and will be published separately.
first opinion
A former CDC director on the major threats to America's health
After the last meeting of the CDC's Advisory Committee on Immunization Practices, it's clear that ending universal hepatitis B birth-dose vaccination is on the table in the U.S. In a new First Opinion essay, former CDC director Tom Frieden argues that this is just the latest example of a troubling trend: "Retreat from proven, lifesaving interventions not because they failed, but because they succeed," as he puts it.
In his new book, published today, Frieden outlines three key steps in a formula to improve understanding and combat threats to public and personal health. "See what's invisible, believe change is possible, and create solutions that work at scale," he writes. Read more.
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