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How dementia treatment became 'exciting'

October 27, 2025
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Morning Rounds Writer and Reporter
Good morning. It's time to start last-minute Halloween costume planning! You've got five days to come up with something. Best of luck. (@ myself.)

exclusive

How to win an FDA priority review voucher (so far)

Earlier this month, the FDA announced the first nine recipients of the Commissioner's National Priority Review vouchers, a program offering an expedited drug review to companies with products that align with the agency's national health priorities. When the program was first announced over the summer, the criteria for eligible companies was somewhat vague, though the agency referenced addressing unmet health needs, beefing up domestic manufacturing, and delivering more innovative cures as potential qualifications.

So how were these nine companies actually picked? STAT's Lizzy Lawrence spoke and emailed with all the recipients to learn more about their therapies and how they secured vouchers. She found out there were a vast array of experiences. While five companies actively applied to the program, the other four were surprised to learn they were selected. 

Read more to learn about the drugs — which target fertility, Type 1 diabetes, addiction, deafness, blindness, and more — and how they were chosen.


fertility

Trends from 27 years of IVF treatments in the U.K.

For women age 43 and up, the most successful fertility treatments occur with donor eggs, according to a study published last night in Population Studies. With one's own eggs, just 5% of treatments resulted in pregnancy, while using donor eggs resulted in successful treatments more than a third of the time. 

The study authors say it's the most comprehensive analysis to date of the effects that age and egg source can have on success rates for fertility treatment. They analyzed all procedures using assisted reproductive technologies in the U.K. between 1991 and 2018, adding up to more than 1.2 million treatment cycles and half a million patients. Here are a few more interesting takeaways:

  • The number of people who initiate fertility treatments every year went up from 6,000 in 1991 to nearly 25,000 in 2018. Overall success rates increased dramatically in that same time, from nearly 15% in 1991 to 28% in 2018.
  • In 2018, more than half of the mothers ages 43-44 who used assistive reproductive technology to have a baby did so with donor eggs. Among those ages 45-50, more than 90% used donor eggs.

biotech

Chinese biotech is not slowing down

There's a rivalry heating up between Chinese and American biotech companies — and their respective governments. The Trump administration has prioritized onshoring American drug manufacturing (biotech lingo for bringing it back to U.S. soil) and considered restricting the flow of medicines from China specifically. The Chinese government is also taking steps to support its homegrown industry. But amid all the talk, STAT contributor Brian Yang reports that Chinese drugmakers are still striking major deals with their global counterparts — including some in the U.S.

"The reality is that you're seeing a lot of global innovation shift to China, and as drug development migrates to China, American investments are migrating there too," said Scott Gottlieb, a former FDA commissioner. Read more from Brian on the state of affairs.  



first opinion

When did dementia treatment get so … exciting? 

An illustrated scientist with short hair and big glasses puts together a puzzle that seems to be of a brain and a test tube.

Molly Ferguson for STAT 

Physician Jason Karlawish still remembers the first patient he diagnosed with Parkinson's disease. After prescribing a treatment, the patient went from miserably house-bound to happily walking the neighborhood with his wife. "The couple called me their miracle worker," Karlawish recalls.

But caring for people with dementia has never been that exciting, Karlawish explains in his latest First Opinion essay. Physicians have generally accepted that there's nothing to be done for dementia patients. That same perspective has kept the Penn Memory Center, where Karlawish works, from getting more than one or two fellowship applicants a year. But recently, something's changed. Last year, there were nine applicants to the program, and new patient requests have skyrocketed. The reason? Karlawish points to biomarker-based therapeutics. Read more about what that means, and why it's given him a renewed sense of hope for treating dementia. It's the third installment in his Neurotransmissions column.


policy

A new study proposes 'cost-neutral' food taxes

Around the country, states are considering new laws aimed at encouraging consumers to make healthy choices at the grocery store. Financial disincentives for sugary drinks in particular are a cornerstone of the Make America Healthy Again movement. But a new study in Ecological Economics proposes a slightly more complex tax system that takes into account the impact that different foods have on both our health and the climate. 

Based on models of Swedish data, the study authors propose introducing taxes on things like sugary drinks, beef, lamb, pork, and processed meat. To offset those price increases, they recommend removing taxes from healthy items like fruit, vegetables, legumes, and whole grain products. This way, the final bill at the end of a grocery trip won't go up, they argue. Making these changes could prevent about 700 premature deaths each year in Sweden, the authors calculated, in addition to greatly reducing the country's climate footprint from food consumption.

Even if laws like this could be beneficial in the U.S. — the study authors believe the results are relevant for most other high-income countries — it would be very difficult to get the American public behind a tax on meat, as STAT's Sarah Todd pointed out to me. (Beef prices have been rising for other reasons lately, and last week President Trump suggested buying meat from Argentina could help lower the costs.) 


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