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The sting of losing research on a contested illness: American Science, Shattered

December 22, 2025
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Morning Rounds Writer and Reporter
Good morning! I hope everyone has a week of many cookies and few emails ahead. You'll hear from me once more this year, tomorrow. 

health

How safe is food in the U.S.?

Oranges and onions sit in a huge pile in the grocery store.

FREDERIC J. BROWN/AFP via Getty Images

In any given year in the U.S., contaminated food causes around 48 million illnesses and 3,000 deaths. And food experts predict that the Trump administration's spending cuts will leave more people exposed to potential foodborne illness in the future. 

"It's not that they are necessarily choosing to harm the system," former CDC leader Daniel Jernigan told STAT's Sarah Todd about the administration. "It's that all of these cuts that are not coherent are all working against each other, and therefore you end up with a system that's just not functioning well."

Particular concerns include: the reduced number of pathogens now monitored by a key surveillance program, brain drain of the foodborne illness staff at the CDC and FDA, and cuts to the administrative staff who support FDA inspectors. Read more from Sarah on how the changes could be impacting food safety — and importantly, how we'll know if the system has broken down.


notable quotable

'While many may celebrate so-called successes gained for women over the last 30 years, one must ask what defines true success for women?'

That's a quote from this NPR story about Bethany Kozma, who last week took a job leading the HHS Office of Global Affairs. As the story details, Kozma has a record of public statements equating abortion with "murder" and railing against the existence of transgender people.

Her appointment comes as the Trump administration and Republicans have substantially ramped up their efforts targeting gender-affirming care for trans youth. Last week the House passed two bills and CMS introduced two major rules for hospitals, all with the intent of restricting youth access to puberty blockers, hormones, and (though it's already rarely provided to young people) surgery.


first opinion

We may not be done with Ozempic for Alzheimer's

But first, Prozac. "Prozac not only changed depression treatment," neurologist Jason Karlawish writes in his latest column. "It changed us." Why is this relevant? Karlawish points to Prozac as an example of an iconic drug that steadily changes people and alters our collective understanding of concepts like free will and individual selfhood. Ozempic is another iconic drug with massive potential, Karlawish argues.

Read the essay from Karlawish, who grapples with this month's disappointing data on the use of GLP-1s for Alzheimer's, and theorizes what lessons we can still learn.



special report

'An itch like a panic attack'

A man stares solemnly at the camera in his uniform from the Public Health Service. Shadows cross over his face.

André Chung for STAT 

After a decade of treating patches of eczema with topical steroids, something changed when Kelly Barta stopped using the prescription creams. A new itch took over — a "bone-deep itch … an itch like a panic attack, an itch so intense you can't think of anything, you literally want to claw your skin off, you don't care if it's bleeding."

Barta diagnosed herself with topical steroid withdrawal in 2012. Historically, it's been a disputed, ill-understood condition that dermatologists and researchers have been reluctant to dig into. But a decade later, she connected with a researcher who was willing to help investigate it. In 2024, allergist-immunologist Ian Myles (above) finished his first study on potential treatments for TSW. He was planning a more extensive follow-up when the Trump administration began. 

In the final installment of American Science, Shattered, STAT's Eric Boodman writes about the slow progress toward understanding one contested illness — and how even small steps forward have been threatened by the administration's cuts. Read more.


one big number

5%

That's how much homelessness could increase within a year if federal funding for Housing First programs (which provide stable housing without requiring sobriety or the initiation of treatment) is eliminated, according to a study in JAMA Health Forum. These policies have been more successful than treatment-first models in helping unhoused populations stay off the street and reducing the level of care they require. But in July, President Trump signed an executive order that called for an end to discretionary funding of these programs.


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What we're reading

  • Worried about health insurance costs? There may be cheaper options — but with trade-offs, The 19th

  • 3 key issues to watch at FDA as Makary struggles to stabilize the agency, STAT
  • The role of doctors is changing forever, New Yorker
  • Why Denmark's vaccine schedule works for Denmark — but not for the United States, STAT

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