supply chain
Drug shortages ease, but the system is fragile
U.S. prescription drug shortages edged up slightly at the end of 2025 but remained well below the early-2024 peak. Last year, 216 medicines were in short supply, compared to 323 a year earlier, according to a new report from the American Society of Health-System Pharmacists.
The number of new shortages fell to just 89 last year — the lowest level since 2006 — and most active shortages began in 2022 or later, suggesting some long-standing problems are easing. Still, ASHP cautioned that more than 200 shortages persist, the supply chain remains vulnerable due to just-in-time inventories, and a single shortage can affect large numbers of patients.
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nih
NIH expands ban on fetal tissue in research
The National Institutes of Health said it will no longer fund research using human fetal tissue derived from abortions, expanding restrictions first imposed during President Trump's initial term and later rolled back under President Biden.
The policy, long pushed by anti-abortion groups, applies to all NIH-funded work, even as scientists argue fetal tissue — otherwise discarded — remains critical for certain studies, including HIV and cancer research, and lacks adequate substitutes.
Use of such tissue has declined since 2019. The $47 billion agency counted just 77 projects funded in 2024 that included fetal tissue.
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Correction: Tuesday's newsletter incorrectly stated that a U.K. trial of individualized medicines would have 11 patients. It will have 10.
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