RESEARCH
Premature menopause raises heart disease risk
If your menstrual periods end before you reach 40, you might face a sharply higher risk of coronary heart disease, according to a new JAMA Cardiology study. It's unclear why, but the study's findings are particularly worrisome for Black women, who are three times more likely than white women to enter premature menopause.
Researchers have tied premature menopause to short-term heart disease before, but the new research looked at six ongoing studies of more than 10,000 women without coronary heart disease whose health was tracked from 1964 to 2018. Among the 3,522 Black women studied, 15.5% had premature menopause; among the 6,514 white women, 4.8% did.
While the culprit raising the risk of disease is still unknown, scientists have some ideas. Read more from STAT's Elizabeth Cooney to find out what we know and what we don't about premature menopause.
VACCINES
Latest update on hepatitis B trial in Guinea-Bissau
Where do things stand with the controversial clinical trial of the hepatitis B vaccine birth dose that the CDC agreed to fund, the one to be conducted in Guinea-Bissau? That's a question without a clear answer, it appears.
Earlier this week it was reported that the University of Southern Denmark had put the trial, proposed by some of its researchers, on a full hold, with the dean of health sciences saying a WHO research ethics committee had agreed to review the protocol.
But on Wednesday, Kate O'Brien, head of WHO's immunization and vaccinations program, said that while the university had made that request, the global health agency hadn't yet replied. O'Brien said it's the responsibility of funders and the home institutions of researchers to ensure a proposed study's protocol is ethical. — Helen Branswell
ONE BIG NUMBER
Did we undercount Covid deaths by 155,000?
The official U.S. death toll during the early days of the Covid-19 pandemic might be much higher than previously thought.
About 840,000 COVID-19 deaths were reported on death certificates in 2020 and 2021. But a group of researchers — using AI — estimate that as many as 155,000 unrecognized additional deaths likely occurred in that time outside of hospitals. That's missing roughly 16% of the relevant deaths.
If we missed this gigantic swath of people, whose deaths, specifically, did we miss? Mostly Hispanic people and other people of color in the South and Southwest. Read more about the findings.
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