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Epstein's 'great friend' returns to biotech

March 11, 2026
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Morning Rounds Writer and Reporter

Good morning. It's amazing what two days of sun and spring-like warmth can do for my mental health. For a more metaphorical change in the weather, read Rose's story below on the administration's changing tune regarding leucovorin. And scroll down further for another Epstein deep dive.

policy

On leucovorin, a pivot

The front sign of the FDA building, seen from a sort of Dutch angle, with a lab dish circular overlay

Sarah Silbiger/Getty Images/STAT

About six months after top health officials touted leucovorin as a drug with the potential to help "hundreds of thousands" of children with autism, the FDA approved the generic drug yesterday. Except it wasn't approved to treat autism, but rather a rare brain disorder, cerebral folate deficiency, that resembles autism.

As STAT's O. Rose Broderick writes, the approval is welcome news for the (roughly) one per one million Americans living with the rare condition, which limits the delivery of folate, a kind of vitamin B, to the brain. It also signals a Trump administration retreat from the idea that the drug holds great promise as an autism treatment. Read more from Rose on where things stand now.


research

Red states hit hardest by reduced NIH funding

Over the past several months, NIH Director Jay Bhattacharya has talked about expanding the spread of NIH funding across the country, moving money away from elite universities on the coasts. While this isn't a new idea — some in academia have called for diversified spending for years — many researchers have interpreted the Trump administration's shift as a way to divert more funding to red states.

But a new report from United for Medical Research shows that, over the past year, red states were harder hit by the lower number of 2025 awards. The report, on the economic returns on NIH funding, found that every dollar invested by the agency spurs about $2.50 in economic activity. But in 2025, 19 states and Washington, D.C., saw decreases of more than 10% in the number of awards they received. Of those 20, 16 voted for Trump in the 2024 elections.

You can read some of STAT's previous reporting on why red states, by and large, did not have terminated grants reinstated — and how it impacted researchers already stretched thin — here. We also wrote about the difficulty measuring the economic returns on NIH funding, and how that can make it difficult for advocates to communicate the impact of disruptions at the agency here. — Anil Oza 


first opinion

Do med schools teach preventative care? 

When she started medical school, Lauren Rice was excited to learn how she could shape her patients' health through nutrition, lifestyle, and preventive medicine. But having nearly finished medical school, she's realizing those topics have largely been absent from her training.

"As I'm poised to graduate, I feel unprepared to address the chronic diseases that will affect the patients I will soon care for," Rice writes in a new First Opinion essay. In other words: Health secretary Robert F. Kennedy Jr., who argues that medical training doesn't pay enough attention to nutrition and lifestyle, may have a point. Read more from a medical student in the trenches on what she sees as missed opportunities to introduce evidence-based education on prevention and lifestyle medicine.



exclusive

Epstein's 'great friend' returns to biotech

nikolic-2-1600x900

Illustration: Camille MacMillin/STAT; Source photo: Department of Justice 

Boris Nikolic was Bill Gates' top science adviser when he was introduced to Jeffrey Epstein in 2009, one year after Epstein's conviction for soliciting sex from minors. Epstein immediately took Nikolic under his wing, urging his new friend to start managing Gates' biotech investments.

The relationship took off from there — DOJ records, many of which are being reported on by STAT for the first time, show how Epstein assisted Nikolic through career moves to become a well-connected biotech investor. The pair also developed a close personal connection, with Nikolic and his now-husband repeatedly sending pictures of young women to Epstein, offering to make introductions; Epstein also advised Nikolic in a heated pre-nup negotiation before the marriage.

Some details on Nikolic's relationship with the convicted sex offender came to light in 2019, seemingly derailing his career. His story, as it relates to STAT's interests, could have ended there. But as Damian Garde reports, one of the most influential venture capitalists in the industry quietly stayed loyal to Nikolic over the intervening years.

"I wish I knew in 2019 or 2024 what I know now," investor Alexis Borisy said in a statement. Borisy helped Nikolic launch a fund, and used his own high-profile venture firm to vouch for the outcast. "However since I did not know then, I stand by my actions to not respond to the impulses of cancel culture." Read more from Damian on the web of connections and where Nikolic, who denies any wrongdoing, has landed.


mental health

A new study parses sex differences in suicide

It's sometimes called the gender paradox in suicide: Women have suicidal thoughts and attempt suicide more often than men, but more men ultimately die by suicide. To analyze the potential genetic influences on these disparities, researchers analyzed data from 3.1 million people born between 1963 and 1998 in Sweden. The study, published yesterday in BMJ Mental Health, found that, while genes play a substantial role in a person's overall risk for suicide, they don't seem to be important when it comes to the differences between sexes.

The records linked each patient with their parents, as well as full and half siblings. Broadly, the risk for an attempted suicide was higher for people with relatives who had also attempted suicide. That increased risk was even higher among first degree relatives — parents, full siblings — than with half siblings. But these familial risk clusters were particularly dangerous for women. For example, in mother-daughter pairs where one person had attempted suicide, the risk for the other to attempt was greater than among father-son pairs. The risk was highest — substantially so — among sisters.

What does it mean? Basically, genetics don't account for the gender paradox in suicide. The study authors believe that social factors and the "potential sex-specific effects of shared familial environment" play a larger role. More research is, as always, necessary.


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