health
Why PCOS might get a new name

Maria Fabrizio for STAT
Researchers have long taken issue with the name "polycystic ovary syndrome," or PCOS, for the endocrinological disorder that can cause intense pain and infertility. Technically, the ovaries don't show cysts, but arrested follicles. And while it's framed as a reproductive condition, it's actually much more complex. Still, the movement to rename PCOS has been both controversial and slow. Now, another consideration has entered the conversation:
"Do you think there is a male version of PCOS that just hasn't been named yet?" That's how one man, Al Barrus, posed the question to Reddit last year. He's not the only one wondering. Some researchers argue that PCOS should be considered a metabolic disease that impacts hormone levels, insulin resistance, and more. This means that when it runs in the family (which it typically does), people without ovaries could be impacted, too. Barrus, whose two sisters have PCOS diagnoses, would be the classic case. Read more from STAT's Annalisa Merelli on the complicated, sometimes secret discussions around changing the name for PCOS.
first opinion
What if we're wrong about medical marijuana?
That's the question posed in a new First Opinion essay by Kevin Sabet, who leads Smart Approaches to Marijuana, an advocacy group pushing for "a middle road between incarceration and legalization," as its website says.
Thirty-eight states and D.C. allow clinicians to recommend medical marijuana for PTSD. But a new systematic review of randomized controlled trials involving marijuana suggests they're wrong, Sabet argues. "Marijuana is far more dangerous than commonly understood, especially today's ultra-high-potency products," he writes, calling the increased normalization of marijuana use over the last few decades "a public health disaster." Read more on his perspective on the evidence.
more science
Testing the benefit of 'coaches' in ketamine therapy
And let's end with more drug talk: As ketamine treatment clinics proliferate across the country, providers are split on whether they should use the drug strictly as a pharmacological intervention or incorporate psychotherapy or another type of supervision alongside it. While studies have shown the drug alone can have immediate benefits, some researchers suspect that there are greater advantages to be gleaned.
STAT's O. Rose Broderick spoke with Harvard psychiatrist Franklin King about a study he's working on to test the feasibility of adding psychological support in the form of "coaches" to ketamine administration. "Coaching comprises a lot of the things that you would get in psychotherapy, but it tends to have much more flexibility," he told Rose. Read their conversation about his research, the importance of regulation, and how coaches might measure up against traditional psychotherapists.
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